{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T09:19:31Z","timestamp":1766481571021,"version":"3.48.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Congenital heart defects (CHDs) are caused by a complex interaction between numerous genetic and environmental risk factors, some of which may differ between different populations. A case\u2013control study was conducted among 1232 newborns, including 308 patients with isolated CHDs (cases) and 924 infants without birth defects (controls), born all during the period 2009\u20132023 at the Hospital Civil de Guadalajara \u201cDr. Juan I. Menchaca\u201d (Guadalajara, Mexico). Potential parental risk factors for CHDs were compared using multivariate logistic regression analysis to evaluate the deviance explained by different variables of interest. Consanguinity [adjusted odds ratio (aOR)\u2009=\u20093.3; 95% confidence interval (CI) 1.3\u20138.5], relatives with CHD (aOR\u2009=\u20098.5; 95% CI 5.3\u201313.8), maternal first\u2010trimester exposure to diabetes (aOR\u2009=\u20093.5; 95% CI 2.4\u20135.1), hypertension (aOR\u2009=\u20092.6; 95% CI 1.5\u20134.4), alcohol consumption (aOR\u2009=\u20091.5; 95% CI 1.0\u20132.1), and illicit drug use (aOR\u2009=\u20092.4; 95% CI 1.2\u20135.3), as well as for the paternal history of alcohol consumption (aOR\u2009=\u20091.4; 95% CI 1.0\u20131.8) and illicit drug use (aOR\u2009=\u20092.7; 95% CI 1.7\u20134.1), were associated with CHDs. Contrarily, aOR for maternal age \u226419\u2009years (aOR\u2009=\u20090.6; 95% CI 0.4\u20130.8) and maternal first\u2010trimester coffee consumption (aOR\u2009=\u20090.7; 95% CI 0.5\u20130.9) have protective odds. Our results suggest that genetic factors, maternal diseases, environmental exposures, and reproductive factors can increase the occurrence of isolated CHDs in our sample, and they are discussed as clues in its pathogenesis.<\/jats:p>","DOI":"10.1111\/cga.12589","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T04:29:13Z","timestamp":1735273753000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk factors for isolated congenital heart defects in infants from Western Mexico"],"prefix":"10.1111","volume":"65","author":[{"given":"Jessica Paola","family":"Cruz\u2010Cruz","sequence":"first","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetics Unit, Pediatrics Division \u201cDr. Juan I. Menchaca\u201d Civil Hospital of Guadalajara  Guadalajara Jalisco Mexico"},{"name":"Dr. Enrique Corona\u2010Rivera Institute of Human Genetics, Department of Molecular Biology and Genomics, Health Sciences University Center University of Guadalajara  Guadalajara Jalisco Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Nieto\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Service of Cardiology, Pediatrics Division \u201cDr. Juan I. Menchaca\u201d Civil Hospital of Guadalajara  Guadalajara Jalisco Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascuala Berenice","family":"Rivera\u2010Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Service of Cardiology, Pediatrics Division \u201cDr. Juan I. Menchaca\u201d Civil Hospital of Guadalajara  Guadalajara Jalisco Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Pe\u00f1a\u2010Padilla","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetics Unit, Pediatrics Division \u201cDr. Juan I. Menchaca\u201d Civil Hospital of Guadalajara  Guadalajara Jalisco Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucina","family":"Bobadilla\u2010Morales","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetics Unit, Pediatrics Division \u201cDr. Juan I. Menchaca\u201d Civil Hospital of Guadalajara  Guadalajara Jalisco Mexico"},{"name":"Dr. Enrique Corona\u2010Rivera Institute of Human Genetics, Department of Molecular Biology and Genomics, Health Sciences University Center University of Guadalajara  Guadalajara Jalisco Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Corona\u2010Rivera","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetics Unit, Pediatrics Division \u201cDr. Juan I. Menchaca\u201d Civil Hospital of Guadalajara  Guadalajara Jalisco Mexico"},{"name":"Dr. Enrique Corona\u2010Rivera Institute of Human Genetics, Department of Molecular Biology and Genomics, Health Sciences University Center University of Guadalajara  Guadalajara Jalisco Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor Ulises","family":"Rodr\u00edguez\u2010Machuca","sequence":"additional","affiliation":[{"name":"Dr. Enrique Corona\u2010Rivera Institute of Human Genetics, Department of Molecular Biology and Genomics, Health Sciences University Center University of Guadalajara  Guadalajara Jalisco Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Rocio","family":"Valdez\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetics Unit, Pediatrics Division \u201cDr. Juan I. 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