{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T16:47:37Z","timestamp":1770569257816,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,5,2]],"date-time":"2008-05-02T00:00:00Z","timestamp":1209686400000},"content-version":"vor","delay-in-days":7183,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:p>Report of a female fetus aborted at the 25th week of gestation, with severe microcephalus, trigonocephaly, median cleft lip and palate, arhinia, and anophthalmia. On opening of the skull the cranial cavity seemed to be occupied only by hindbrain structures. The forebrain, including the tentorium cerebelli and the falx were absent. However, in the light microscope membraneous remnants of a collapsed forebrain vesicle were found. They were connected with the mid\u2010brain brain and appeared as glio\u2010mesenchymal membranes with an ependymal out\u2010line at their inner surface. There was no cranioschisis. The formal relationship of this forebrain malformation to abobar dorsal sac holoprosencephaly, and its separation from hydranencephaly are discussed. In view of the gross absence of the telencephalon and the microscopic demonstration of remnants of a prosencephalic vesicle it is suggested to term this \u201cmissing link\u201d in the classification of human CNS malformations pseudoaprosencephaly.<\/jats:p>","DOI":"10.1111\/cga.1988.28.3.169","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T16:00:11Z","timestamp":1497456011000},"page":"169-177","source":"Crossref","is-referenced-by-count":4,"title":["Pseudoaprosencephaly: Aplasia of the Forebrain in a Median Facial Cleft Syndrome with Arhinia and Anophthalmia"],"prefix":"10.1111","volume":"28","author":[{"given":"Horst P.","family":"Schmitt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwan A.","family":"Born","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,5,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.33.169.235"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.10.961"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000104278"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-7091-3338-5","volume-title":"Developmental Neuropathology","author":"Friede L.","year":"1975"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1977.tb07973.x"},{"key":"e_1_2_1_7_1","first-page":"194","volume-title":"Handbuch der speziellen pathologischen Anatomie und Histologie, Vol. XIII\/4","author":"Hallervorden J.","year":"1956"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1977.tb08000.x"},{"key":"e_1_2_1_9_1","first-page":"194","volume-title":"Handbuch der speziellen pathologischen Anatomie und Histologie, Vol. XIII\/4","author":"Hallervorden J.","year":"1956"},{"key":"e_1_2_1_10_1","volume-title":"Methodik und erste Ergebnisse ciner Kyematologie","author":"Kloos K.F.","year":"1974"},{"key":"e_1_2_1_11_1","first-page":"1","volume-title":"Die embryonale Entwicklung. Entwicklungsphysiologie und experimentelle Pathologie. Handbuch der allgemeine Pathologie, Vol. VI\/I","author":"Lehmann F.E.","year":"1955"},{"key":"e_1_2_1_12_1","volume-title":"Normal and Abnormal Development of the Human Nervous System","author":"Lemire R.J.","year":"1975"},{"key":"e_1_2_1_13_1","volume-title":"Aenecephaly","author":"Lemire R.J.","year":"1978"},{"key":"e_1_2_1_14_1","first-page":"157","article-title":"An experimental observation on the morphogenesis of reopening of the cranium","volume":"12","author":"Murakami U.","year":"1972","journal-title":"Cong. Anom."},{"key":"e_1_2_1_15_1","first-page":"283","volume-title":"Missbildungen. 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Hydrocephalus im fr\u00fchen Kindesalter","author":"Schwechheimer K.","year":"1983"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(69)80224-6"},{"key":"e_1_2_1_23_1","first-page":"315","article-title":"Experimental production of congenital malformations in rat by salicylate poisoning. Am","volume":"35","author":"Warkany J.","year":"1959","journal-title":"J. Pathol."},{"key":"e_1_2_1_24_1","first-page":"620","article-title":"Generation of anencephaly: 1. Aberrant neurolation, 2. Conversion of exencephaly to anencephaly. J. Neuropathol","volume":"43","author":"Wood L.R.","year":"1984","journal-title":"Exp. 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