{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T09:19:39Z","timestamp":1766481579166,"version":"3.48.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The current case report presents the postmortem examination findings of a 17\u2010week\u2010old female fetus displaying thanatophoric dysplasia type 1 (TD\u20101) due to a known fibroblast growth factor receptor 3 (FGFR3) gene mutation. Gross and X\u2010ray examination revealed significant abnormalities, including skeletal malformations with prominent TD\u20101 femur curvature. Microscopical evaluation indicated inadequate histological growth for the gestational age, with specific organ immaturity noted in multiple hematoxylin and eosin sections from internal organs, bone from epiphyses and diaphyses levels. Immunohistochemical analysis was conducted using specific markers, such as S100, CD34, CD117, glycophorin\u2010C, and myeloperoxidase, to identify various hematopoietic and mesenchymal cell types. Furthermore, this report underscores the often\u2010overlooked aspect of fetal hematopoiesis in cases diagnosed with TD\u20101, shedding light on the development of hematopoietic cells and their markers in various tissues, with a particular emphasis on the investigation of bone marrow foci in areas with incipient or no apparent ossification. Immunohistochemical identification of hematopoiesis also served as an indirect way to identify areas of incipient or abnormal ossification.<\/jats:p>","DOI":"10.1111\/cga.70004","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T19:25:37Z","timestamp":1736364337000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An immunohistochemical study of thanatophoric dysplasia type 1 after fetus autopsy examination"],"prefix":"10.1111","volume":"65","author":[{"given":"Ioanna","family":"Abba Deka","sequence":"first","affiliation":[{"name":"Department of Surgical Pathology, Medical School Aristotle University of Thessaloniki  Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8607-6695","authenticated-orcid":false,"given":"Paschalis","family":"Theotokis","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical School, Faculty of Health Sciences Aristotle University of Thessaloniki  Greece"},{"name":"2nd Department of Neurology, University General Hospital AHEPA, Medical School Aristotle University of Thessaloniki  Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7075-878X","authenticated-orcid":false,"given":"Maria Eleni","family":"Manthou","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical School, Faculty of Health Sciences Aristotle University of Thessaloniki  Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angeliki","family":"Mathioudi","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical School, Faculty of Health Sciences Aristotle University of Thessaloniki  Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelia","family":"Athanasiou","sequence":"additional","affiliation":[{"name":"Histopathology Laboratory, \u201cMicrodiagnostiki\u201d  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soultana","family":"Meditskou","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical School, Faculty of Health Sciences Aristotle University of Thessaloniki  Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/TACG.S150982"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000231688.08263.47"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61366"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.63132"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891\u2010020\u201003663\u2010x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010023\u201002955\u20104"},{"volume-title":"Thanatophoric dysplasia","year":"2004","author":"French 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