{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T09:19:37Z","timestamp":1766481577755,"version":"3.48.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K17194"],"award-info":[{"award-number":["21K17194"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pregnancy loss is a significant concern worldwide, encompassing miscarriage and stillbirth. Miscarriage, defined as the loss of a baby before 28\u2009weeks of gestation, accounts for approximately 15% of pregnancies. Stillbirth, occurring at or after 28\u2009weeks of gestation, affects nearly 2.0 million pregnancies annually, predominantly in low\u2010 and middle\u2010income regions. This study aims to investigate the potential of Anemarrhena rhizome (AR) herbal medicine in mitigating pregnancy loss and reducing the incidence of cleft palate in A\/J mice models. A total of 390 6\u2010week\u2010old A\/J mice were used for the study. Three different dosages of dried AR (6, 12, and 18\u2009g) were boiled to prepare water extracts. The mice were divided into experimental groups receiving these extracts and a control group. Pregnancy outcomes, including fetal mortality rates and incidence of cleft palate, were assessed. The experimental groups receiving AR herbal medicine demonstrated significantly lower fetal mortality rates compared to the control group. Additionally, the incidence of cleft palate was notably reduced in the experimental groups, with the AR 6\u2009g and AR 12\u2009g groups showing significant reductions compared to the control group. AR herbal medicine shows promise in mitigating pregnancy loss and reducing the incidence of cleft palate in A\/J mice models. These findings suggest the potential of AR as a therapeutic agent for improving fetal health outcomes. Further research is warranted to elucidate the underlying mechanisms and optimize dosage strategies for maximizing its therapeutic benefits in pregnancy\u2010related complications.<\/jats:p>","DOI":"10.1111\/cga.70005","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T18:35:01Z","timestamp":1737657301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Experimental study on the preventive effect of Anemarrhena rhizome on pregnancy loss and the incidence rate of cleft palate in A\/J mice"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2968-5150","authenticated-orcid":false,"given":"Anar\u2010Erdene","family":"Gantugs","sequence":"first","affiliation":[{"name":"Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies School of Dentistry, Aichi Gakuin University  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruyuki","family":"Niimi","sequence":"additional","affiliation":[{"name":"Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies School of Dentistry, Aichi Gakuin University  Nagoya Japan"},{"name":"Cleft Lip and Palate Center Aichi Gakuin University Dental Hospital  Nagoya Japan"},{"name":"Division of Speech, Hearing, and Language Aichi Gakuin University Dental Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Inoue","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Resources School of Pharmacy, Aichi Gakuin University  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3969-3567","authenticated-orcid":false,"given":"Ichinnorov","family":"Chimedtseren","sequence":"additional","affiliation":[{"name":"Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies School of Dentistry, Aichi Gakuin University  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chisato","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies School of Dentistry, Aichi Gakuin University  Nagoya Japan"},{"name":"Cleft Lip and Palate Center Aichi Gakuin University Dental Hospital  Nagoya Japan"},{"name":"Division of Speech, Hearing, and Language Aichi Gakuin University Dental Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagana","family":"Natsume","sequence":"additional","affiliation":[{"name":"Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies School of Dentistry, Aichi Gakuin University  Nagoya Japan"},{"name":"Cleft Lip and Palate Center Aichi Gakuin University Dental Hospital  Nagoya Japan"},{"name":"Division of Speech, Hearing, and Language Aichi Gakuin University Dental Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies School of Dentistry, Aichi Gakuin University  Nagoya Japan"},{"name":"Cleft Lip and Palate Center Aichi Gakuin University Dental Hospital  Nagoya Japan"},{"name":"Division of Speech, Hearing, and Language Aichi Gakuin University Dental Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies School of Dentistry, Aichi Gakuin University  Nagoya Japan"},{"name":"Cleft Lip and Palate Center Aichi Gakuin University Dental Hospital  Nagoya Japan"},{"name":"Division of Speech, Hearing, and Language Aichi Gakuin University Dental Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajnai","family":"Luvsan\u2010Ish","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Informatics School of Biomedicine, Mongolian National University of Medical Sciences  Ulaanbaatar Mongolia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideto","family":"Imura","sequence":"additional","affiliation":[{"name":"Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies School of Dentistry, Aichi Gakuin University  Nagoya Japan"},{"name":"Cleft Lip and Palate Center Aichi Gakuin University Dental Hospital  Nagoya Japan"},{"name":"Division of Speech, Hearing, and Language Aichi Gakuin University Dental Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroo","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Cleft Lip and Palate Center Aichi Gakuin University Dental Hospital  Nagoya Japan"},{"name":"Division of Speech, Hearing, and Language Aichi Gakuin University Dental Hospital  Nagoya Japan"},{"name":"Department of Health Sciences, Faculty of Health Sciences Aichi Gakuin University  Nisshin Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagato","family":"Natsume","sequence":"additional","affiliation":[{"name":"Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies School of Dentistry, Aichi Gakuin University  Nagoya Japan"},{"name":"Cleft Lip and Palate Center Aichi Gakuin University Dental Hospital  Nagoya Japan"},{"name":"Division of Speech, Hearing, and Language Aichi Gakuin University Dental Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"UNICEF: How many babies are born a year?\u2014UNICEF 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