{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T09:19:45Z","timestamp":1766481585938,"version":"3.48.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":117,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Children with Down syndrome often experience obstructive sleep apnea (OSA), which can be severe and, if untreated, leads to serious complications. Polysomnography, the gold standard for diagnosing OSA, has long waiting lists and poses challenges for these children. The modified OSA\u201018 questionnaire may help determine the severity of OSA in this population, facilitating the study of its prevalence and risk factors. A cohort of 180 children with Down syndrome, aged 2\u201312\u2009years, was enrolled from August 2020 to January 2022. Participants completed the modified OSA\u201018 questionnaire, where a score of 21+ indicated a high risk of severe OSA. Demographic data, prevalence, and associated risk variables were analyzed. A total of 180 participants were included. Their mean age was 8.9\u2009\u00b1\u20092.8\u2009years, and a slight majority were male (52.2%). Most had normal weight (44.4%); 33.9% were overweight, and 21.7% had obesity. The prevalence of those at high risk for severe OSA was 19.4%. The only significant risk factor for severe OSA was obesity (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001; OR\u2009=\u20096.96; 95% CI\u2009=\u20092.65\u201318.28). The study found a lower prevalence of high\u2010risk severe OSA in children than reported by polysomnography\u2010based studies, with obesity as the sole risk factor. The research confirmed that the modified OSA\u201018 questionnaire is a more convenient and quicker assessment tool. Prompt assessment of obese children with Down syndrome for severe OSA is crucial to prevent sequelae.\n                  <\/jats:p>","DOI":"10.1111\/cga.70010","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T07:24:43Z","timestamp":1745825083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Using the modified\n                    <scp>OSA<\/scp>\n                    \u2010questionnaire to determine the prevalence of a high risk of severe obstructive sleep apnea in children with Down syndrome"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5633-0787","authenticated-orcid":false,"given":"Vannipa","family":"Vathanophas","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Faculty of Medicine Siriraj Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chotmanee","family":"Panpapai","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Sawanpracharak Hospital  Nakhon Sawan Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archwin","family":"Tanphaichitr","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Faculty of Medicine Siriraj Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wish","family":"Banhiran","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Faculty of Medicine Siriraj Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"volume-title":"Obstructive Sleep Apnea","year":"2021","author":"Slowik JM","key":"e_1_2_10_2_1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7126"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200708-138MG"},{"volume-title":"Thai Guideline for Childhood Obstructive Sleep Apnea","year":"2023","author":"Preutthipan A","key":"e_1_2_10_5_1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2020.109968"},{"key":"e_1_2_10_7_1","first-page":"1","article-title":"Obstructive sleep apnea in individuals with Down syndrome: a meta\u2010analytic literature review","volume":"1","author":"Sharanah R","year":"2017","journal-title":"J Sleep Res"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S154723"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5554"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2016.06.018"},{"key":"e_1_2_10_11_1","article-title":"G518(P) Screening for sleep\u2010related upper airway obstruction in Down syndrome: a population study","volume":"104","author":"Gunasuntharam K","year":"2019","journal-title":"Arch Dis Child"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2013.08.030"},{"key":"e_1_2_10_13_1","first-page":"464","article-title":"Reliability and validity of Thai version quality of life questionnaire (OSA\u201018) for pediatric obstructive sleep apnea","volume":"98","author":"Kuptanon T","year":"2015","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25534"},{"key":"e_1_2_10_15_1","first-page":"427","article-title":"Diagnostic properties modified OSA\u201018 questionnaire in children with severe obstructive sleep apnea","volume":"101","author":"Kaewkul P","year":"2018","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211023102"},{"key":"e_1_2_10_17_1","first-page":"65","article-title":"Effect of weight change on severity of obstructive sleep apnea in childhood obesity","volume":"48","author":"Lilitwat W","year":"2017","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817703921"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818797308"},{"key":"e_1_2_10_20_1","first-page":"1074","article-title":"Treatment considerations for obstructive sleep apnea in pediatric Down syndrome","volume":"8","author":"Gastelum E","year":"2021","journal-title":"Children (Basel)"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24380"}],"container-title":["Congenital Anomalies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cga.70010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T09:17:01Z","timestamp":1766481421000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cga.70010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/cga.70010"],"URL":"https:\/\/doi.org\/10.1111\/cga.70010","archive":["Portico"],"relation":{},"ISSN":["0914-3505","1741-4520"],"issn-type":[{"type":"print","value":"0914-3505"},{"type":"electronic","value":"1741-4520"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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