{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:30:17Z","timestamp":1773095417059,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":148,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to assess the prevalence of soft markers on second\u2010trimester sonography in low\u2010risk and screening na\u00efve Indian antenatal women and determine their association with aneuploidy. Soft markers were evaluated through ultrasound, and likelihood ratios (LRs) and modified risk (MR) for aneuploidy were calculated. Pregnant women with a MR &gt;1:250 underwent genetic counseling and invasive testing, whereas those with a lower risk received follow\u2010up. Associations were estimated via Fisher's exact test. A total of 4051 anomaly scans were reviewed, among which 207 (5.1%) women were found to have soft markers (SMs). These included 153 (3.7%) isolated SMs, 43 (1.06%) multiple SMs, and 11 (0.2%) SMs with structural abnormalities. The most common SM was renal pyelectasis. Invasive test uptake increased by 25% among pregnancies with isolated markers and by 55% for those with multiple SMs. A significant association was found between isolated short femur and aneuploidy (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026), and between multiple SMs and aneuploidy (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.039). Soft markers in low\u2010risk couples can lead to unnecessary invasive testing and anxiety. Genetic counseling is important for discussing relevant factors. Invasive testing for aneuploidies should be based on the modified risk, the presence of multiple SMs, or structural anomalies on ultrasonography.\n                  <\/jats:p>","DOI":"10.1111\/cga.70011","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T02:21:46Z","timestamp":1748571706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Revisiting ultrasonographic soft markers of aneuploidy: A thoughtful analysis in low\u2010risk and screening na\u00efve Indian antenatal women"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-3227","authenticated-orcid":false,"given":"Shreya","family":"Das","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology All India Institute of Medical Sciences  Jodhpur India"},{"name":"Nil Ratan Sircar Medical College &amp; Hospital  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7788-2502","authenticated-orcid":false,"given":"Charu","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology All India Institute of Medical Sciences  Jodhpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taruna","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology All India Institute of Medical Sciences  Jodhpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4612-6533","authenticated-orcid":false,"given":"Shashank","family":"Shekhar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology All India Institute of Medical Sciences  Jodhpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5286-3826","authenticated-orcid":false,"given":"Pratibha","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology All India Institute of Medical Sciences  Jodhpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1268-6973","authenticated-orcid":false,"given":"Garima","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology All India Institute of Medical Sciences  Jodhpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2117-7249","authenticated-orcid":false,"given":"Dolat Singh","family":"Shekhawat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics All India Institute of Medical Sciences  Jodhpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9375-3233","authenticated-orcid":false,"given":"Kuldeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics All India Institute of Medical Sciences  Jodhpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5413-3074","authenticated-orcid":false,"given":"Manisha","family":"Jhirwal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology All India Institute of Medical Sciences  Jodhpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5367-5795","authenticated-orcid":false,"given":"Manoj Kumar","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Community Medicine &amp; Family Medicine All India Institute of Medical Sciences  Jodhpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.5734\/JGM.2018.15.1.1"},{"issue":"1","key":"e_1_2_9_3_1","first-page":"9","article-title":"Ultrasonographic soft markers of aneuploidy in second trimester: Are we lost?","volume":"8","author":"Raniga S","year":"2006","journal-title":"MedGenMed"},{"key":"e_1_2_9_4_1","volume-title":"Callen's Ultrasonography in Obstetrics and Gynecology","author":"Norton ME","year":"2016"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12364"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mefs.2012.04.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12334"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010018\u20101812\u20103"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.24888"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6456"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22145"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.06.079"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.080"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.14366\/usg.16046"},{"key":"e_1_2_9_15_1","unstructured":"Perinatology.com\u2014age adjusted ultrasound risk assessment.https:\/\/www.perinatology.com\/calculators\/Down%20Syndromee%20Revised%20Risk.htm"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2024.108278"},{"key":"e_1_2_9_17_1","volume-title":"IBM SPSS Statistics for Macintosh, Version 23.0","author":"IBM Corp","year":"2015"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4708"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340902934688"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109378(99)70322\u20104"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1725"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2001.20.10.1053"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.02.074"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajum.12074"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.15496"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22095"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1083549"},{"key":"e_1_2_9_28_1","unstructured":"Ministry of Law and Justice Govt of India.The Medical Termination of Pregnancy (Amendment) Act 2021 No. 8 of 2021. The Gazette of India. CG\u2010DL\u2010E\u201026032021\u2010226\u2009130. March 25 2021. Accessed April 23 2024.https:\/\/ruralindiaonline.org\/mr\/library\/resource\/the-medical-termination-of-pregnancy-amendment-act-2021\/"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2002.21.10.1087"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20359"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20101118\u20103974"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15851"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.01.019"}],"container-title":["Congenital Anomalies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cga.70011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T09:17:06Z","timestamp":1766481426000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cga.70011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/cga.70011"],"URL":"https:\/\/doi.org\/10.1111\/cga.70011","archive":["Portico"],"relation":{},"ISSN":["0914-3505","1741-4520"],"issn-type":[{"value":"0914-3505","type":"print"},{"value":"1741-4520","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70011"}}