{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T19:16:02Z","timestamp":1783970162475,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T00:00:00Z","timestamp":1352332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>Trichilemmal cysts (TCs) can occur as sporadic lesions or in hereditary\u2013familial settings with autosomal dominant transmission. These entities have not been widely analyzed in their peculiar aspects yet. The aim of this study was to describe a cohort of patients with diagnosis of <jats:styled-content style=\"fixed-case\">TCs<\/jats:styled-content> through a clinical and biomolecular characterization, intended to highlight some effective diagnostic criteria for their identification. Among 149 cases of this study, 24 cases of <jats:styled-content style=\"fixed-case\">TCs<\/jats:styled-content> (16.1%) arose in patients with at least one first\u2010degree relative with diagnosis of <jats:styled-content style=\"fixed-case\">TCs<\/jats:styled-content>. Peculiar findings concerning hereditary lesions included the multiple presentation with an early onset age. On the basis of clinical evaluation, we propose a panel of clinical and histologic criteria for the diagnosis of hereditary TCs, which includes: (i) the diagnosis of <jats:styled-content style=\"fixed-case\">TCs<\/jats:styled-content> in at least two first\u2010degree relatives or in three first\u2010 or second\u2010degree relatives in two consecutive generations; (ii) at least one of the patients with <jats:styled-content style=\"fixed-case\">TCs<\/jats:styled-content> diagnosed &lt;45\u2009years; and (iii) the diagnosis of multiple or giant (&gt;5\u2010cm lesions) or rare histopathologic features (proliferating and ossifying) <jats:styled-content style=\"fixed-case\">TCs<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cge.12040","type":"journal-article","created":{"date-parts":[[2012,10,15]],"date-time":"2012-10-15T09:34:37Z","timestamp":1350293677000},"page":"65-69","source":"Crossref","is-referenced-by-count":20,"title":["Hereditary trichilemmal cysts: a proposal for the assessment of diagnostic clinical criteria"],"prefix":"10.1111","volume":"84","author":[{"given":"S","family":"Seidenari","sequence":"first","affiliation":[{"name":"Department of Surgical, Medical, Odontoiatric and Morphological Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Pellacani","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical, Odontoiatric and Morphological Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Nasti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties (DiMI) University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Tomasi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Diagnostic Medicine and Public Health, Division of Clinical Pathology University Hospital of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Pastorino","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties (DiMI) University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Ghiorzo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties (DiMI) University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ruini","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical, Odontoiatric and Morphological Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Bianchi\u2010Scarr\u00e0","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties (DiMI) University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Pollio","sequence":"additional","affiliation":[{"name":"Oral Medicine Unit, Department of Odontostomatological and Maxillofacial Sciences, School of Medicine and Surgery Federico II University of Naples  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VD","family":"Mandel","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical, Odontoiatric and Morphological Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Ponti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Diagnostic Medicine and Public Health, Division of Clinical Pathology University Hospital of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1977.tb01533.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stomax.2011.10.008"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1962.01590100044012"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02982314"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/oxfordjournals.jhered.a106931","article-title":"Hereditary multiple sebaceous cysts","volume":"50","author":"Stephens FE","year":"1959","journal-title":"J Hered"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30568"},{"key":"e_1_2_5_8_1","first-page":"549","article-title":"The FLOTCH syndrome. 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