{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:20:04Z","timestamp":1789003204113,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T00:00:00Z","timestamp":1354147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>Short stature skeletal dysplasia (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) patients have orthopedic and neurologic complications causing significant pain and physical disability. We conducted a large cross\u2010sectional online survey in 361 people with short stature <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> (&gt;10\u2009years) to describe pain prevalence, characteristics, and the relationship between pain and function. Chronic pain prevalence per Brief Pain Inventory (BPI) was 70.3%. Women reported more pain than men (73% <jats:italic>vs<\/jats:italic> 63% p\u2009=\u20090.04). Pain Severity Score (average of current, worst, least and average pain) averaged 3.3\u2009\u00b1\u20092, while the Pain Interference Score (with daily activities) averaged 3.4\u2009\u00b1\u20092.7 on a 10\u2010point scale. Per Bleck scale, 20.5% had little or no functional capacity. Increasing age and decreased ambulation independently predicted chronic pain. Chronic pain is prevalent in short stature <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> patients and associated with poor physical function. Further study is required to clarify the temporal relationship among pain, function and treatments.<\/jats:p>","DOI":"10.1111\/cge.12045","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T13:41:11Z","timestamp":1351172471000},"page":"237-243","source":"Crossref","is-referenced-by-count":51,"title":["Cross\u2010sectional assessment of pain and physical function in skeletal dysplasia patients"],"prefix":"10.1111","volume":"84","author":[{"given":"Y","family":"Alade","sequence":"first","affiliation":[{"name":"Alan and Kathryn Greenberg Center for Skeletal Dysplasias, McKusick\u2010Nathans Institute of Genetic Medicine Johns Hopkins University  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Tunkel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Division of Pediatric Otolaryngology Johns Hopkins University  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Schulze","sequence":"additional","affiliation":[{"name":"Alan and Kathryn Greenberg Center for Skeletal Dysplasias, McKusick\u2010Nathans Institute of Genetic Medicine Johns Hopkins University  Baltimore MD USA"},{"name":"Centers for Human Nutrition, Department of International Health Johns Hopkins Bloomberg School of Public Health  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"McGready","sequence":"additional","affiliation":[{"name":"Alan and Kathryn Greenberg Center for Skeletal Dysplasias, McKusick\u2010Nathans Institute of Genetic Medicine Johns Hopkins University  Baltimore MD USA"},{"name":"Department of Biostatistics Johns Hopkins Bloomberg School of Public Health  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Jallo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Division of Pediatric Neurosurgery Johns Hopkins University  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ain","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Division of Pediatric Orthopedics Johns Hopkins University  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Yost","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Division of Pediatric Orthopedics Johns Hopkins University  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hoover\u2010Fong","sequence":"additional","affiliation":[{"name":"Alan and Kathryn Greenberg Center for Skeletal Dysplasias, McKusick\u2010Nathans Institute of Genetic Medicine Johns Hopkins University  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33909"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32485"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31919"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3171\/2010.3.SPINE09629"},{"key":"e_1_2_6_6_1","first-page":"33","article-title":"Osteogenesis imperfecta","volume":"57","author":"Bhadada SK","year":"2009","journal-title":"J Assoc Physicians India"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.35.9.705"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980616)78:1<30::AID-AJMG7>3.0.CO;2-P"},{"issue":"2","key":"e_1_2_6_9_1","first-page":"129","article-title":"Pain assessment: global use of the brief pain inventory","volume":"23","author":"Cleeland CS","year":"1994","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2003.12.005"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00343-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-003-0574-3"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00355-9"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2010.07.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2010.07.004"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000080153.36643.83"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCN.0b013e3181cd66be"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980616)78:1<1::AID-AJMG1>3.0.CO;2-V"},{"key":"e_1_2_6_19_1","unstructured":"Cleeland CS. 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