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Evaluation of exclusion prenatal and exclusion preimplantation genetic diagnosis for Huntington's disease in the Netherlands.<\/jats:p><jats:p>Individuals at 50% risk of Huntington's disease (HD) who prefer not to know their carrier status, might opt for exclusion prenatal diagnosis (ePND) or exclusion preimplantation genetic diagnosis (ePGD). This study aims to provide a better understanding of couples' motives for choosing ePND or ePND, and surveys couples' experiences in order to make recommendations for the improvement of counselling for exclusion testing. This qualitative retrospective interview study focussed on couples who underwent ePND or ePGD for HD in the period 1996\u20132010. Seventeen couples were included of which 13 had experienced ePND and 6 ePGD. Mean time\u2010interval since exclusion\u2010testing was 3.9 years. Couples' moral reservations regarding termination of pregnancy (TOP) or discarding healthy embryos were counterbalanced by the wish to protect their future child against HD. Seven couples had terminated a total of 11 pregnancies with a 50% HD risk, none showed regret. ePGD was used by couples who wanted to avoid (another) TOP. ePND and ePGD are acceptable reproductive options for a specific group of counsellees. To guarantee sound standards of care, it is imperative that candidate couples be given in\u2010depth non\u2010directive counselling about all possible scenarios, and adequate professional and psychological support prior to, during and after ePND\/ePGD.<\/jats:p>","DOI":"10.1111\/cge.12058","type":"journal-article","created":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T23:36:37Z","timestamp":1352417797000},"page":"118-124","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of exclusion prenatal and exclusion preimplantation genetic diagnosis for Huntington's disease in the Netherlands"],"prefix":"10.1111","volume":"83","author":[{"given":"MC","family":"van Rij","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CEM","family":"de Die\u2010Smulders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EK","family":"Bijlsma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GMWR","family":"de Wert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JP","family":"Geraedts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAC","family":"Roos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Tibben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,14]]},"reference":[{"key":"e_1_2_9_2_2","volume-title":"Huntington's disease","author":"Bates G","year":"2002"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3109"},{"key":"e_1_2_9_4_2","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"HDCRG","year":"1993","journal-title":"Cell"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2003.00093.x"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200781"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.37.8.567"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200871"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2006.00701.x"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199905)19:5<450::AID-PD568>3.0.CO;2-L"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6486.1929"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.30.7.549"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.32.2.97"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200865"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201291"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2011.202"},{"key":"e_1_2_9_17_2","unstructured":"Ross\u2010van DorpCIJM.Letter of the State Secretary of Public Health and Sport Vol. 30 300 XVI nr 36. 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