{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:01:24Z","timestamp":1775800884852,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2014,1]]},"abstract":"We aimed to study reproductive behaviour of couples opting for prenatal diagnosis (PND<\/jats:styled-content>) and pre\u2010implantation genetic diagnosis (PGD<\/jats:styled-content>) for Huntington's disease (HD<\/jats:styled-content>). In the Netherlands, exclusion PND<\/jats:styled-content> is available for persons at 50% risk, whereas exclusion PGD<\/jats:styled-content> is not allowed. All 162 couples who underwent PND<\/jats:styled-content> or PGD<\/jats:styled-content> for HD<\/jats:styled-content> between 1998 and 2008 and referrals for exclusion PGD<\/jats:styled-content> to Belgium were included. Couples' reproductive information was collected until December 2010; 132 couples (81.5%) underwent PND<\/jats:styled-content> in 262 pregnancies, 54 (33.3%) started PGD<\/jats:styled-content>, and 25 used both. Sixteen percent of PND<\/jats:styled-content> couples used exclusion PND<\/jats:styled-content> and 6% used exclusion PGD<\/jats:styled-content>. The outcomes were 76.5% of PND<\/jats:styled-content> couples delivered \u22651 unaffected child(ren) after PND<\/jats:styled-content>, and 44.4% of PGD<\/jats:styled-content> couples delivered \u22651 PGD<\/jats:styled-content> child(ren) (mean 2.5\u2009cycles\/couple). Couples opting for PGD<\/jats:styled-content> secondarily (after a previous pregnancy) had more frequently terminated a pregnancy for HD<\/jats:styled-content> (87.0%) compared with couples secondarily opting for PND<\/jats:styled-content> (55.2%; p\u2009=\u20090.015). At\u2010risk or HD<\/jats:styled-content> expansion carrier males were underrepresented in the group of couples primarily opting for PGD<\/jats:styled-content> (25%) and overrepresented in the secondary PGD<\/jats:styled-content> group (64%). We conclude that couples reconsider their choices in every subsequent pregnancy based on their previous experience, personal beliefs and the gender of the at\u2010risk partner.<\/jats:p>","DOI":"10.1111\/cge.12089","type":"journal-article","created":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T15:14:58Z","timestamp":1359126898000},"page":"87-95","source":"Crossref","is-referenced-by-count":17,"title":["The uptake and outcome of prenatal and pre\u2010implantation genetic diagnosis for Huntington's disease in the Netherlands (1998\u20132008)"],"prefix":"10.1111","volume":"85","author":[{"given":"MC","family":"van Rij","sequence":"first","affiliation":[{"name":"Department of Clinical Genetics Maastricht University Medical Centre (MUMC) Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAM","family":"de Koning Gans","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Leiden University Medical Centre (LUMC) Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MJ","family":"van Belzen","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Leiden University Medical Centre (LUMC) Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAC","family":"Roos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JPM","family":"Geraedts","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Maastricht University Medical Centre (MUMC) Maastricht The Netherlands"},{"name":"GROW, Research School for Oncology and Developmental Biology Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"De Rademaeker","sequence":"additional","affiliation":[{"name":"Centre for Medical Genetics University Hospital Brussels Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EK","family":"Bijlsma","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Leiden University Medical Centre (LUMC) Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CEM","family":"de Die\u2010Smulders","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Maastricht University Medical Centre (MUMC) Maastricht The Netherlands"},{"name":"GROW, Research School for Oncology and Developmental Biology Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,21]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Huntington's disease","author":"Harper P","year":"1996"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-40"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3109"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"HDCRG","year":"1993","journal-title":"Cell"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199905)19:5<450::AID-PD568>3.0.CO;2-L"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.69.5.579"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200871"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000484792"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20583"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.31.7.555"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201291"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200865"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2011.202"},{"key":"e_1_2_7_15_1","unstructured":"Ross\u2010van DorpCIJM. 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