{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:37:10Z","timestamp":1791250630471,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,2,20]],"date-time":"2013-02-20T00:00:00Z","timestamp":1361318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>Studies suggest that patients carrying a <jats:italic><jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content><\/jats:italic> variant of uncertain significance (<jats:styled-content style=\"fixed-case\">VUS<\/jats:styled-content>) may have lingering confusion concerning results interpretation. Counseling for uninformative <jats:italic><jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content><\/jats:italic>\u2010negative (<jats:styled-content style=\"fixed-case\">UN<\/jats:styled-content>) results is thought to be more straightforward, despite the fact that both results lead to similar methods of empiric cancer risk counseling. This study compared surgical choices and perceptions between 71 patients with <jats:styled-content style=\"fixed-case\">VUS<\/jats:styled-content> results and 714 patients with <jats:styled-content style=\"fixed-case\">UN<\/jats:styled-content> results. All patients underwent genetic counseling because of a personal or family history of breast or ovarian cancer between 1997 and 2010, and completed a 2\u2010year follow\u2010up survey. Risk\u2010reducing mastectomy rates in both groups were 7% (p\u2009=\u20091.00) and risk\u2010reducing oophorectomy rates were 5% and 3%, respectively (p\u2009=\u20090.42). The <jats:styled-content style=\"fixed-case\">VUS<\/jats:styled-content> group reported less cancer distress reduction than the <jats:styled-content style=\"fixed-case\">UN<\/jats:styled-content> group (23.0% <jats:italic>vs<\/jats:italic> 35.8%, respectively, p\u2009=\u20090.043). Over 90% of both groups found the counseling process helpful. Overall, the study suggests that <jats:styled-content style=\"fixed-case\">VUS<\/jats:styled-content> results disclosed in genetic counseling did not cause excessive surgery or exaggerated cancer distress, though patients with a <jats:styled-content style=\"fixed-case\">VUS<\/jats:styled-content> found counseling somewhat less informative or reassuring. Future research on communication of <jats:styled-content style=\"fixed-case\">VUS<\/jats:styled-content> results, including pre\u2010and post\u2010test counseling, is essential for full realization of the potential for genomic medicine.<\/jats:p>","DOI":"10.1111\/cge.12097","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T09:52:50Z","timestamp":1358416370000},"page":"464-472","source":"Crossref","is-referenced-by-count":89,"title":["Variants of uncertain significance in <i><scp>BRCA<\/scp><\/i> testing: evaluation of surgical decisions, risk perception, and cancer distress"],"prefix":"10.1111","volume":"84","author":[{"given":"JO","family":"Culver","sequence":"first","affiliation":[{"name":"Division of Clinical Cancer Genetics City of Hope  Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CD","family":"Brinkerhoff","sequence":"additional","affiliation":[{"name":"Department of Genetics and Metabolism University of California  Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Clague","sequence":"additional","affiliation":[{"name":"Division of Clinical Cancer Genetics City of Hope  Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Clinical Cancer Genetics City of Hope  Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KE","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Genetics and Metabolism University of California  Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SR","family":"Sand","sequence":"additional","affiliation":[{"name":"Division of Clinical Cancer Genetics City of Hope  Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JN","family":"Weitzel","sequence":"additional","affiliation":[{"name":"Division of Clinical Cancer Genetics City of Hope  Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/521032"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1209372109"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20128"},{"key":"e_1_2_8_5_1","volume-title":"Estimated variant rate for a next\u2010generation sequencing panel of 13 genes associated with hereditary colon cancer","author":"Stuenkel AJ","year":"2012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.06.022"},{"key":"e_1_2_8_7_1","unstructured":"Saam J Burbidge L Bowles K et al. 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