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Social withdrawal and inconsolable crying often developed simultaneously (9\/14), with social withdrawal for shorter duration than inconsolable crying. Previously acquired gross motor skills declined in just over half of the sample (8\/14), mostly observed as a loss of balance. Early abnormalities such as vomiting and strabismus were also seen. Our findings provide additional insight into the early clinical profile of Rett syndrome.<\/jats:p>","DOI":"10.1111\/cge.12110","type":"journal-article","created":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T07:04:21Z","timestamp":1359097461000},"page":"572-576","source":"Crossref","is-referenced-by-count":48,"title":["Early development and regression in Rett syndrome"],"prefix":"10.1111","volume":"84","author":[{"given":"JYL","family":"Lee","sequence":"first","affiliation":[{"name":"School of Psychology and Speech Pathology and Curtin Health Innovation Research Institute Curtin University Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Leonard","sequence":"additional","affiliation":[{"name":"Telethon Institute for Child Health Research, Centre for Child Health Research University of Western Australia Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JP","family":"Piek","sequence":"additional","affiliation":[{"name":"School of Psychology and Speech Pathology and Curtin Health Innovation Research Institute Curtin University Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Downs","sequence":"additional","affiliation":[{"name":"Telethon Institute for Child Health Research, Centre for Child Health Research University of Western Australia Perth Australia"},{"name":"School of Physiotherapy and Curtin Health Innovation Research Institute Curtin University Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3182242461"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22124"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1469-8749.1998.tb15371.x","article-title":"Is the girl with Rett syndrome normal at birth?","volume":"40","author":"Leonard H","year":"1998","journal-title":"Dev Med Child Neurol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000155945.94249.0A"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073811401396"},{"key":"e_1_2_6_7_1","first-page":"4","volume-title":"Rett Syndrome \u2013 Clinical and Biological Aspects","author":"Hagberg B","year":"1993"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(02)00058-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(87)80069-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1993.tb141373.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738030180100301"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22851"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.072553"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(94)90082-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-007-0569-x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2005.03.023"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327078IN0102_1"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcge.12110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cge.12110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T05:31:11Z","timestamp":1714887071000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cge.12110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,11]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/cge.12110"],"URL":"https:\/\/doi.org\/10.1111\/cge.12110","archive":["Portico"],"relation":{},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,11]]}}}