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Between February 2001 and December 2011, a total of 1050 individuals requested their inclusion in the presymptomatic testing (PST) program. Their medical records were retrospectively analyzed in the present descriptive study. A total of 768 participants completed the protocol, 204 withdrew and 78 were excluded. The PST uptake was 24.91%. Females predominated and 70.96% had negative test results. Their main motivations were risk assessment in their descendants, physical and psychological preparation to cope with the disease and planning for the future. The profile of Cuban participants in the predictive testing program is similar to the one reported for other programs all over the world, nevertheless the genetic counseling practice at the community level is a distinctive aspect, which is valuable in providing at\u2010risk individuals with wide and proper knowledge before their testing inclusion request. The <jats:styled-content style=\"fixed-case\">SCA2<\/jats:styled-content> predictive testing program has high uptake rates and is renowned in our population. Future research is needed to assess the long\u2010term psychological impact in the participants, their partners and relatives.<\/jats:p>","DOI":"10.1111\/cge.12142","type":"journal-article","created":{"date-parts":[[2013,3,16]],"date-time":"2013-03-16T05:13:01Z","timestamp":1363410781000},"page":"518-524","source":"Crossref","is-referenced-by-count":19,"title":["The\u2009Cuban program for predictive testing of <scp>SCA2<\/scp>: 11\u2009years and 768 individuals to learn from"],"prefix":"10.1111","volume":"83","author":[{"given":"T","family":"Cruz\u2010Mari\u00f1o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Vel\u00e1zquez\u2010P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Gonz\u00e1lez\u2010Zaldivar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Aguilera\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Clinical Department Center for the Research and Rehabilitation of Hereditary Ataxias  Holgu\u00edn Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Vel\u00e1zquez\u2010Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"V\u00e1zquez\u2010Mojena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Estupi\u00f1\u00e1n\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Clinical Department Center for the Research and Rehabilitation of Hereditary Ataxias  Holgu\u00edn Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JM","family":"Laffita\u2010Mesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Reynaldo\u2010Armi\u00f1\u00e1n","sequence":"additional","affiliation":[{"name":"International Relationships Department Medical University of Holgu\u00edn  Holgu\u00edn Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LE","family":"Almaguer\u2010Mederos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Paneque","sequence":"additional","affiliation":[{"name":"Center for Predictive and Preventive Genetics IBMC\u2014Institute for Molecular and Cell Biology  University of Porto  Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.30.12.1028"},{"key":"e_1_2_7_3_1","first-page":"123","volume-title":"O Teste Preditivo da Doen\u00e7a de Machado\u2010Joseph","author":"Sequeiros J","year":"1996"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/344768a0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1909"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-011-0265-2"},{"key":"e_1_2_7_7_1","first-page":"77","volume-title":"Spinocerebellar ataxia","author":"Vel\u00e1zquez PL","year":"2012"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.03.015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1196-277"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1196-285"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1196-269"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000101754"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-006-9083-y"},{"issue":"1","key":"e_1_2_7_14_1","first-page":"15","article-title":"Medical genetic services in Cuba","volume":"1","author":"Lantigua CA","year":"2007","journal-title":"Rev Cubana Genet Comunit"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-009-9240-1"},{"key":"e_1_2_7_16_1","unstructured":"HDSA. 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