{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:07:30Z","timestamp":1791587250605,"version":"4.3.4"},"reference-count":90,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T00:00:00Z","timestamp":1365465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>Beckwith\u2013Wiedemann syndrome (<jats:styled-content style=\"fixed-case\">BWS<\/jats:styled-content>) and Silver\u2013Russell syndrome (<jats:styled-content style=\"fixed-case\">SRS<\/jats:styled-content>) are two congenital disorders with opposite outcomes on fetal growth, overgrowth and growth restriction, respectively. Although both disorders are heterogeneous, most cases of <jats:styled-content style=\"fixed-case\">BWS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SRS<\/jats:styled-content> are associated with opposite epigenetic or genetic abnormalities on 11p15.5 leading to opposite imbalances in the expression levels of imprinted genes. In this article, we review evidence implicating these genes in the developmental regulation of embryonic growth and placental function in mouse models. The emerging picture suggests that both <jats:styled-content style=\"fixed-case\">SRS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BWS<\/jats:styled-content> can be caused by the simultaneous and opposite deregulation of two groups of imprinted genes on 11p15.5. A detailed description of the phenotypic abnormalities associated with each syndrome must take into consideration the developmental functions of each gene involved.<\/jats:p>","DOI":"10.1111\/cge.12143","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T23:13:37Z","timestamp":1363389217000},"page":"326-334","source":"Crossref","is-referenced-by-count":43,"title":["Beckwith\u2013Wiedemann and Silver\u2013Russell syndromes: opposite developmental imbalances in imprinted regulators of placental function and embryonic growth"],"prefix":"10.1111","volume":"84","author":[{"given":"KJ","family":"Jacob","sequence":"first","affiliation":[{"name":"Life Sciences Institute, Molecular Epigenetics Group University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WP","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Child &amp; Family Research Institute  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