{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T04:29:47Z","timestamp":1783225787830,"version":"3.54.6"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T00:00:00Z","timestamp":1365465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>The frequency of <jats:italic><jats:styled-content style=\"fixed-case\">BRCA1<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">BRCA2<\/jats:styled-content><\/jats:italic> mutations is higher in Israel than in almost all other countries. One strategy to reduce the burden of hereditary breast and ovarian cancers is to offer genetic testing followed by risk\u2010reducing surgery (mastectomy and salpingo\u2010oophorectomy) for mutation carriers. The extent to which Israeli women who carry mutations undergo these surgeries is not well characterized. Israeli women who are <jats:italic><jats:styled-content style=\"fixed-case\">BRCA1<\/jats:styled-content><\/jats:italic> or <jats:italic><jats:styled-content style=\"fixed-case\">BRCA2<\/jats:styled-content><\/jats:italic> mutation carriers and followed at a single high\u2010risk clinic were asked to complete a questionnaire detailing their clinical histories at the time of genetic results disclosure and a follow\u2010up questionnaire was completed 18 or more months thereafter. A total of 205 mutation carriers completed the questionnaires. Of 170 women with no cancer history, 84 (49%) had a risk\u2010reducing bilateral salpingo\u2010oophorectomy and 22 (13%) had a risk\u2010reducing mastectomy. Five of 35 (14.3%) women with breast cancer opted for contralateral mastectomy. Approximately one half of Israeli women with a <jats:italic><jats:styled-content style=\"fixed-case\">BRCA1<\/jats:styled-content><\/jats:italic> or <jats:italic><jats:styled-content style=\"fixed-case\">BRCA2<\/jats:styled-content><\/jats:italic> mutation opt for risk\u2010reducing oophorectomy, but the rate of risk\u2010reducing mastectomy is only 13%.<\/jats:p>","DOI":"10.1111\/cge.12149","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T13:37:32Z","timestamp":1363786652000},"page":"68-71","source":"Crossref","is-referenced-by-count":20,"title":["Rates of risk\u2010reducing surgery in Israeli <i><scp>BRCA1<\/scp><\/i> and <i><scp>BRCA2<\/scp><\/i> mutation 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