{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:42:13Z","timestamp":1791373333141,"version":"4.3.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T00:00:00Z","timestamp":1365465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>The aims of this study were to estimate the prevalence of familial cases in patients with Meniere's disease (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>) and to identify clinical differences between sporadic and familial <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>. We recruited 1375 patients with definite <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> according to the American Academy of Otolaryngology\u2010Head and Neck Surgery criteria, obtaining the familial history of hearing loss or episodic vertigo by direct interview or a postal survey in 1245 cases in a multicenter study. Familial clustering was estimated by the recurrence risk ratio in siblings (<jats:italic>\u03bb<\/jats:italic><jats:sub>s<\/jats:sub>) and offspring (<jats:italic>\u03bb<\/jats:italic><jats:sub>o<\/jats:sub>) using intermediate and high prevalence values for <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> in European population. A total of 431 patients (34%) reported a familial history of hearing loss or recurrent vertigo and 133 patients had a relative with possible <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>. After clinical reevaluation, 93 relatives in 76 families were diagnosed of definite <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> (8.4%), including three pairs of monozygotic twins. <jats:italic>\u03bb<\/jats:italic><jats:sub>s<\/jats:sub> and <jats:italic>\u03bb<\/jats:italic><jats:sub>o<\/jats:sub> were 16\u201348 and 4\u201312, respectively. We observed genetic heterogeneity, but most families had an autosomal dominant inheritance with anticipation. No clinical differences were found between sporadic and familial <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>, except for an early onset in familial cases. We may conclude that <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> has a strong familial aggregation and that sporadic and familial <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>s are clinically identical.<\/jats:p>","DOI":"10.1111\/cge.12150","type":"journal-article","created":{"date-parts":[[2013,3,23]],"date-time":"2013-03-23T20:14:02Z","timestamp":1364069642000},"page":"245-252","source":"Crossref","is-referenced-by-count":128,"title":["Familial clustering and genetic heterogeneity in Meniere's disease"],"prefix":"10.1111","volume":"85","author":[{"given":"T.","family":"Requena","sequence":"first","affiliation":[{"name":"Otology &amp; Neurotology Group CTS495, Human DNA Variability Department \u2010 Centro de Gen\u00f3mica e Investigaci\u00f3n Oncol\u00f3gica Pfizer\/Universidad de Granada\/ Junta de Andaluc\u00eda (GENYO)  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Espinosa\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Otology &amp; Neurotology Group CTS495, Human DNA Variability Department \u2010 Centro de Gen\u00f3mica e Investigaci\u00f3n Oncol\u00f3gica Pfizer\/Universidad de Granada\/ Junta de Andaluc\u00eda (GENYO)  Granada Spain"},{"name":"Department of Otorhinolaryngology Hospital San Agustin  Linares Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Otology &amp; Neurotology Group CTS495, Human DNA Variability Department \u2010 Centro de Gen\u00f3mica e Investigaci\u00f3n Oncol\u00f3gica Pfizer\/Universidad de Granada\/ Junta de Andaluc\u00eda (GENYO)  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Trinidad","sequence":"additional","affiliation":[{"name":"Division of Otoneurology, Department of Otorhinolaryngology Complejo Hospitalario Badajoz  Badajoz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Soto\u2010Varela","sequence":"additional","affiliation":[{"name":"Division of Otoneurology, Department of Otorhinolaryngology Complexo Hospitalario Universitario  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Santos\u2010Perez","sequence":"additional","affiliation":[{"name":"Division of Otoneurology, Department of Otorhinolaryngology Complexo Hospitalario Universitario  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Teggi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology San Raffaelle Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Hospital Cabue\u00f1es  Gij\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Batuecas\u2010Caletrio","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hospital Universitario Salamanca  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fraile","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hospital Miguel Servet  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Aran","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Complexo Hospitalario de Pontevedra  Pontevedra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hospital Universitario de Getafe  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Benitez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hospital Universitario de Gran Canaria Dr Negrin  Las Palmas Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"P\u00e9rez\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Clinica Universidad de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Lopez\u2010Escamez","sequence":"additional","affiliation":[{"name":"Otology &amp; 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