{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:20:56Z","timestamp":1789680056275,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T00:00:00Z","timestamp":1394064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"FWO Flanders","award":["G029107"],"award-info":[{"award-number":["G029107"]}]},{"name":"FWO Flanders","award":["G.0594.09"],"award-info":[{"award-number":["G.0594.09"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Children with unexplained developmental disabilities or congenital anomalies are increasingly being referred for genetic diagnostic testing using array\u2010comparative genomic hybridisation (array\u2010<jats:styled-content style=\"fixed-case\">CGH<\/jats:styled-content>) and next\u2010generation sequencing (<jats:styled-content style=\"fixed-case\">NGS<\/jats:styled-content>) technologies. Their parents will have to deal with the secondary variants that will inevitably arise. We conducted 16 prospective semi\u2010structured interviews with native Dutch\u2010speaking parents whose children had undergone clinical array\u2010<jats:styled-content style=\"fixed-case\">CGH<\/jats:styled-content> testing. The interviews explored the parents' experiences, expectations and opinions, specifically regarding the communication of results. Concrete examples of \u2018unexpected results\u2019 were provided to help guide the discussion, differing in severity, treatability, time of onset, level of risk, and carrier status. Data was analysed using content and narrative analysis methodologies. Parental motivations for and against the disclosure of unexpected results cluster around four main themes: actionability; knowledge; context; and characteristics of the result. Most parents wished to know all types of results. Disclosure was framed within a holistic, contextual, family\u2010wide view. Genetic counselling should aim to integrate explorations of the motivations of parents surrounding the disclosure of results with good clinical care.<\/jats:p>","DOI":"10.1111\/cge.12354","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T13:16:54Z","timestamp":1391087814000},"page":"207-216","source":"Crossref","is-referenced-by-count":20,"title":["The communication of secondary variants: interviews with parents whose children have undergone array\u2010<scp>CGH<\/scp> testing"],"prefix":"10.1111","volume":"86","author":[{"given":"G.M.","family":"Christenhusz","sequence":"first","affiliation":[{"name":"Centre for Biomedical Ethics and Law Catholic University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Devriendt","sequence":"additional","affiliation":[{"name":"Centre for Human Genetics Catholic University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Peeters","sequence":"additional","affiliation":[{"name":"Centre for Human Genetics Catholic University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Van Esch","sequence":"additional","affiliation":[{"name":"Centre for Human Genetics Catholic University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Dierickx","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Ethics and Law Catholic University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.04.006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.9.081307.164359"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181b0cbd8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.191"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.2.212"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2013.08.006"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.63"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-013-0145-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12254"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35554"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2013.89"},{"key":"e_1_2_6_13_1","unstructured":"ArkseyH.Collecting data through joint interviews. 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