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This study presents results from patients who underwent hereditary colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>) panel\u2010based testing (\u2018<jats:styled-content style=\"fixed-case\">ColoNext<jats:sup>\u2122<\/jats:sup><\/jats:styled-content>\u2019). De\u2010identified data from a clinical testing laboratory were used to calculate (1) frequencies for patient demographic, clinical, and family history variables and (2) rates of pathogenic mutations and variants of uncertain significance (<jats:styled-content style=\"fixed-case\">VUS<\/jats:styled-content>). The proportion of individuals with a pathogenic mutation who met national syndrome\u2010based testing criteria was also determined. Of 586 patients, a pathogenic mutation was identified in 10.4%, while 20.1% had at least one <jats:styled-content style=\"fixed-case\">VUS<\/jats:styled-content>. After removing eight patients with <jats:italic><jats:styled-content style=\"fixed-case\">CHEK2<\/jats:styled-content><\/jats:italic> mutations and 11 <jats:italic><jats:styled-content style=\"fixed-case\">MUTYH<\/jats:styled-content><\/jats:italic> heterozygotes, the percentage of patients with \u2018actionable\u2019 mutations that would clearly alter cancer screening recommendations per national guidelines decreased to 7.2%. Of 42 patients with an \u2018actionable\u2019 result, 30 (71%) clearly met established syndrome\u2010based testing guidelines. This descriptive study is among the first to report on a large clinical series of patients undergoing panel\u2010based testing for inherited <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>. Results are discussed in the context of benefits and concerns that have been raised about panel\u2010based testing implementation.<\/jats:p>","DOI":"10.1111\/cge.12359","type":"journal-article","created":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T02:54:37Z","timestamp":1392000877000},"page":"510-520","source":"Crossref","is-referenced-by-count":86,"title":["Panel\u2010based testing for inherited colorectal cancer: a descriptive study of clinical testing performed by a US laboratory"],"prefix":"10.1111","volume":"86","author":[{"given":"D.","family":"Cragun","sequence":"first","affiliation":[{"name":"H. 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