{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:13:01Z","timestamp":1790676781472,"version":"4.1.0"},"reference-count":96,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,5,10]],"date-time":"2014-05-10T00:00:00Z","timestamp":1399680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>\n                    Dental care costs in the United States exceed $100 billion annually. Personalized medicine efforts in dentistry are driven by potentially compelling clinical utility and cost\u2010effectiveness prospects in the major diseases of periodontitis, caries, and oral cancers. This review discusses progress and challenges identifying genetic markers and showing clinical utility in dentistry. Genome\u2010wide association studies (\n                    <jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content>\n                    ) of chronic periodontitis (\n                    <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\n                    ) identified no significant variants, but\n                    <jats:styled-content style=\"fixed-case\">CDKN2BAS<\/jats:styled-content>\n                    variants on chromosome 9 were significantly associated with aggressive periodontitis. Stratifying patients by interleukin (IL)\u20101 gene variants, smoking and diabetes differentiated\n                    <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\n                    prevention outcomes. Dental caries'\n                    <jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content>\n                    identified significant signals in\n                    <jats:styled-content style=\"fixed-case\">LYZL2<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">AJAp1<\/jats:styled-content>\n                    , and\n                    <jats:styled-content style=\"fixed-case\">KPNA4<\/jats:styled-content>\n                    ; and efforts are ongoing to identify genetic factors for multiple caries phenotypes. Trials of molecularly targeted therapies are in progress for oral, head, and neck squamous cell carcinomas (\n                    <jats:styled-content style=\"fixed-case\">OHNSCC<\/jats:styled-content>\n                    ) and results have been promising but limited in their effectiveness. Current opportunities and challenges for molecular targeting for\n                    <jats:styled-content style=\"fixed-case\">OHNSCC<\/jats:styled-content>\n                    are discussed.\n                  <\/jats:p>","DOI":"10.1111\/cge.12396","type":"journal-article","created":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T04:51:19Z","timestamp":1396846279000},"page":"44-49","source":"Crossref","is-referenced-by-count":36,"title":["Clinical application of genetics to guide prevention and treatment of oral diseases"],"prefix":"10.1111","volume":"86","author":[{"given":"K.S.","family":"Kornman","sequence":"first","affiliation":[{"name":"Department of R&amp;D Interleukin Genetics  Waltham MA USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"Polverini","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan School of Dentistry  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,10]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Chronic Disease Prevention and Health Promotion.2012 from:http:\/\/www.cdc.gov\/chronicdisease\/resources\/publications\/AAG\/doh.htm. 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