{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:51:10Z","timestamp":1781916670119,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T00:00:00Z","timestamp":1400112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>Dupuytren's disease (<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>) is a progressive fibromatosis that causes the formation of nodules and cords in the palmar aponeurosis leading to flexion contracture of affected fingers. The etiopathogenesis is multifactorial with a strong genetic predisposition. It is the most frequent genetic disorder of connective tissues. We have collected clinical data from 736 unrelated individuals with <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> who underwent surgical treatment from Germany and Switzerland. We evaluated a standardised questionnaire, assessed the importance of different risk factors and compared subgroups with and without positive family history. We found that family history clearly had the strongest influence on the age at first surgery compared to environmental factors, followed by male sex. Participants with a positive family history were on average 55.9\u2009years of age at the first surgical intervention, 5.2\u2009years younger than probands without known family history (p\u2009=\u20096.7\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>). The percentage of familial cases decreased with age of onset from 55% in the 40\u201349 years old to 17% at age 80\u2009years or older. Further risk factors analysed were cigarettes, alcohol, diabetes, hypertension, and epilepsy. Our data pinpoint the importance of genetic susceptibility for <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>, which has long been underestimated.<\/jats:p>","DOI":"10.1111\/cge.12410","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T11:26:55Z","timestamp":1398166015000},"page":"483-487","source":"Crossref","is-referenced-by-count":33,"title":["The importance of genetic susceptibility in Dupuytren's disease"],"prefix":"10.1111","volume":"87","author":[{"given":"K.","family":"Becker","sequence":"first","affiliation":[{"name":"Cologne Center for Genomics"},{"name":"Cluster of Excellence on Cellular Stress Responses in Aging\u2010associated Diseases University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tinschert","sequence":"additional","affiliation":[{"name":"Division of Human Genetics Innsbruck Medical University  Innsbruck Austria"},{"name":"Institute of Clinical Genetics Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lienert","sequence":"additional","affiliation":[{"name":"Praxis Dr. Peter E. Bleuler  R\u00fcti Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.E.","family":"Bleuler","sequence":"additional","affiliation":[{"name":"Praxis Dr. Peter E. Bleuler  R\u00fcti Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Staub","sequence":"additional","affiliation":[{"name":"Center for Peripheral Neurosurgery  Dossenheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Meinel","sequence":"additional","affiliation":[{"name":"Center for Peripheral Neurosurgery  Dossenheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"R\u00f6\u00dfler","sequence":"additional","affiliation":[{"name":"Praxis Dr. J\u00f6rg R\u00f6\u00dfler Marcolini\u2010Praxisklinik  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Wach","sequence":"additional","affiliation":[{"name":"International Dupuytren Society  \u00dcbersee Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Institute for Hand and Plastic Surgery  Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"K\u00fchnel","sequence":"additional","affiliation":[{"name":"Department for Trauma, Hand, and Reconstructive Surgery Carl\u2010Thiem\u2010Klinikum Cottbus  Cottbus Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010G.","family":"Damert","sequence":"additional","affiliation":[{"name":"Department for Plastic, Aesthetic, and Hand Surgery University Hospital of Magdeburg  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010E.","family":"Nick","sequence":"additional","affiliation":[{"name":"Department for Plastic Surgery St.\u2010Antonius\u2010Hospital  Eschweiler Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Spicher","sequence":"additional","affiliation":[{"name":"Center for Hand and Reconstructive Surgery Roland\u2010Klinik Bremen  Bremen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Lenze","sequence":"additional","affiliation":[{"name":"Praxis Drs. 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