{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:12:12Z","timestamp":1761718332742},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T00:00:00Z","timestamp":1410825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>Men with a <jats:styled-content style=\"fixed-case\"><jats:italic>BRCA2<\/jats:italic><\/jats:styled-content> mutation face substantial lifetime risks for the development of both breast and prostate cancer. A male who was initially diagnosed with breast cancer at the age of 32 was subsequently diagnosed at age 77 with both contralateral breast cancer and prostate cancer. He was found to be <jats:styled-content style=\"fixed-case\"><jats:italic>BRCA2<\/jats:italic><\/jats:styled-content> mutation carrier. The patient was treated with contralateral mastectomy, breast irradiation, prostate irradiation and adjuvant endocrine therapy. At age 83 he died of metastatic prostate cancer. Our case underscores the observation that <jats:styled-content style=\"fixed-case\"><jats:italic>BRCA2<\/jats:italic><\/jats:styled-content> mutation carriers are at risk for multiple cancers, including contralateral breast cancer, and illustrates the need for current practice recommendations for the early detection of breast and prostate cancer in men with <jats:styled-content style=\"fixed-case\"><jats:italic>BRCA2<\/jats:italic><\/jats:styled-content> mutations.<\/jats:p>","DOI":"10.1111\/cge.12478","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T08:14:15Z","timestamp":1407831255000},"page":"187-189","source":"Crossref","is-referenced-by-count":2,"title":["Prostate cancer in a man with a <i><scp>BRCA2<\/scp><\/i> mutation and a personal history of bilateral breast cancer"],"prefix":"10.1111","volume":"88","author":[{"given":"C. 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