{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:46:35Z","timestamp":1788871595896,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T00:00:00Z","timestamp":1414454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"crossref","award":["RSGT-00-263-01"],"award-info":[{"award-number":["RSGT-00-263-01"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"crossref","award":["RC4A153828"],"award-info":[{"award-number":["RC4A153828"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>\n                    The prevalence of\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">BRCA1<\/jats:styled-content>\n                    <\/jats:italic>\n                    and\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">BRCA2<\/jats:styled-content>\n                    <\/jats:italic>\n                    mutations among breast cancer patients in Peru has not yet been explored. We enrolled 266 women with breast cancer from a National cancer hospital in Lima, Peru, unselected for age or family history.\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    was screened with a panel of 114 recurrent Hispanic\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content>\n                    <\/jats:italic>\n                    mutations (\n                    <jats:styled-content style=\"fixed-case\">HISPANEL<\/jats:styled-content>\n                    ). Among the 266 cases, 13 deleterious mutations were identified (11 in\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">BRCA1<\/jats:styled-content>\n                    <\/jats:italic>\n                    and 2 in\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">BRCA2<\/jats:styled-content>\n                    <\/jats:italic>\n                    ), representing 5% of the total. The average age of breast cancer in the mutation\u2010positive cases was 44\u2009years.\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">BRCA1<\/jats:styled-content>\n                    <\/jats:italic>\n                    <jats:styled-content style=\"fixed-case\">185delAG<\/jats:styled-content>\n                    represented 7 of 11 mutations in\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">BRCA1<\/jats:styled-content>\n                    <\/jats:italic>\n                    . Other mutations detected in\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">BRCA1<\/jats:styled-content>\n                    <\/jats:italic>\n                    included: two\n                    <jats:styled-content style=\"fixed-case\">2080delA<\/jats:styled-content>\n                    , one 943ins10, and one\n                    <jats:styled-content style=\"fixed-case\">3878delTA<\/jats:styled-content>\n                    . The\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">BRCA2<\/jats:styled-content>\n                    <\/jats:italic>\n                    3036del4 mutation was seen in two patients. Given the relatively low cost of the\n                    <jats:styled-content style=\"fixed-case\">HISPANEL<\/jats:styled-content>\n                    test, one should consider offering this test to all Peruvian women with breast or ovarian cancer.\n                  <\/jats:p>","DOI":"10.1111\/cge.12505","type":"journal-article","created":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T15:33:59Z","timestamp":1411659239000},"page":"371-375","source":"Crossref","is-referenced-by-count":50,"title":["Prevalence of\n                    <i>\n                      <scp>BRCA1<\/scp>\n                    <\/i>\n                    and\n                    <i>\n                      <scp>BRCA2<\/scp>\n                    <\/i>\n                    mutations in unselected breast cancer patients from Peru"],"prefix":"10.1111","volume":"88","author":[{"given":"J.","family":"Abugattas","sequence":"first","affiliation":[{"name":"Departamento de Mamas, Partes Blandas y Piel Instituto Nacional de Enfermedades Neopl\u00e1sicas  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Llacuachaqui","sequence":"additional","affiliation":[{"name":"Familial Breast Cancer Research Unit Women's College Research Institute  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. Sullcahuaman","family":"Allende","sequence":"additional","affiliation":[{"name":"Unidad de Gen\u00e9tica y Biolog\u00eda Molecular Instituto Nacional de Enfermedades Neopl\u00e1sicas  Lima Peru"},{"name":"Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Arias","family":"Vel\u00e1squez","sequence":"additional","affiliation":[{"name":"Unidad de Gen\u00e9tica y Biolog\u00eda Molecular Instituto Nacional de Enfermedades Neopl\u00e1sicas  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Velarde","sequence":"additional","affiliation":[{"name":"Departamento de Mamas, Partes Blandas y Piel Instituto Nacional de Enfermedades Neopl\u00e1sicas  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Cotrina","sequence":"additional","affiliation":[{"name":"Departamento de Mamas, Partes Blandas y Piel Instituto Nacional de Enfermedades Neopl\u00e1sicas  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Garc\u00e9s","sequence":"additional","affiliation":[{"name":"Departamento de Mamas, Partes Blandas y Piel Instituto Nacional de Enfermedades Neopl\u00e1sicas  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Mamas, Partes Blandas y Piel Instituto Nacional de Enfermedades Neopl\u00e1sicas  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Calder\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Mamas, Partes Blandas y Piel Instituto Nacional de Enfermedades Neopl\u00e1sicas  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"de la Cruz","sequence":"additional","affiliation":[{"name":"Departamento de Mamas, Partes Blandas y Piel Instituto Nacional de Enfermedades Neopl\u00e1sicas  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Mora","sequence":"additional","affiliation":[{"name":"Departamento de Mamas, Partes Blandas y Piel Instituto Nacional de Enfermedades Neopl\u00e1sicas  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Royer","sequence":"additional","affiliation":[{"name":"Familial Breast Cancer Research Unit Women's College Research Institute  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Herzog","sequence":"additional","affiliation":[{"name":"City of Hope Comprehensive Cancer Center and Beckman Research Institute Division of Clinical Cancer Genetics  Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.N.","family":"Weitzel","sequence":"additional","affiliation":[{"name":"City of Hope Comprehensive Cancer Center and Beckman Research Institute Division of Clinical Cancer Genetics  Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.A.","family":"Narod","sequence":"additional","affiliation":[{"name":"Familial Breast Cancer Research Unit Women's College Research Institute  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,28]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Globocan 2002. 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