{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T13:39:53Z","timestamp":1784381993276,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T00:00:00Z","timestamp":1415404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>Huntington disease (HD) is a late\u2010onset, fatal neurodegenerative disorder caused by a (<jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content>) triplet repeat expansion in the <jats:italic>Huntingtin<\/jats:italic> gene that enlarges during male meiosis. In 1996 in this journal, one of us (<jats:styled-content style=\"fixed-case\">J.\u2009D.\u2009S.<\/jats:styled-content>) presented a methodology to perform pre\u2010implantation genetic diagnosis in families at\u2010risk for <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> without revealing the genetic status of the at\u2010risk parent. Despite the introduction of accurate prenatal and pre\u2010implantation genetic testing which can prevent transmission of the abnormal <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> gene in the family permanently, utilization of these options is extremely low. In this article, we examine the decision\u2010making process regarding genetic testing in families with <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> and discuss the possible reasons for the low uptake among this group.<\/jats:p>","DOI":"10.1111\/cge.12523","type":"journal-article","created":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T07:53:03Z","timestamp":1413186783000},"page":"220-223","source":"Crossref","is-referenced-by-count":13,"title":["Low utilization of prenatal and pre\u2010implantation genetic diagnosis in Huntington disease\u00a0\u2013\u00a0risk discounting in preventive genetics"],"prefix":"10.1111","volume":"88","author":[{"given":"J.D.","family":"Schulman","sequence":"first","affiliation":[{"name":"Genetics &amp; IVF Institute Reproductive Genetics  Fairfax VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9366-2964","authenticated-orcid":false,"given":"H.J.","family":"Stern","sequence":"additional","affiliation":[{"name":"Genetics &amp; IVF Institute Reproductive Genetics  Fairfax VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,8]]},"reference":[{"key":"e_1_2_2_2_1","volume-title":"Huntington's disease","author":"Bates G","year":"2002"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-006-9080-1"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1996.tb04327.x"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2003.00093.x"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199812)18:13<1422::AID-PD499>3.0.CO;2-R"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms058"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2009.11.017"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25075"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.359"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr052"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2013.818545"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-7-200304010-00012"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.04.044"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1611(200011\/12)9:6<504::AID-PON491>3.0.CO;2-R"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-004-7991-2"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcge.12523","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cge.12523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:57:37Z","timestamp":1696334257000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cge.12523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,8]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/cge.12523"],"URL":"https:\/\/doi.org\/10.1111\/cge.12523","archive":["Portico"],"relation":{},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,8]]}}}