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Several other cancer susceptibility genes have been identified, but their value in routine clinical genetic testing is still unclear. Germline mutations in <jats:italic><jats:styled-content style=\"fixed-case\">RAD51C<\/jats:styled-content><\/jats:italic> have been identified in about 1% of hereditary breast and ovarian cancer families. <jats:italic><jats:styled-content style=\"fixed-case\">RAD51C<\/jats:styled-content><\/jats:italic> mutations are predominantly found in families with a history of ovarian cancer and are rare in families with a history of breast cancer alone. <jats:italic><jats:styled-content style=\"fixed-case\">RAD51C<\/jats:styled-content><\/jats:italic> is primarily an ovarian cancer susceptibility gene. A mutation is present in approximately 1% of unselected ovarian cancers. Among mutation carriers, the lifetime risk of ovarian cancer is approximately 9%. The average age at onset is approximately 60\u2009years; this suggests that preventive oophorectomy can be delayed until after natural menopause. Under current guidelines, genetic testing for <jats:italic><jats:styled-content style=\"fixed-case\">RAD51C<\/jats:styled-content><\/jats:italic> is expected to have a limited impact on ovarian cancer incidence at a population level. This is because the penetrance is 9% to age 80; the great majority of families with mutations would be represented by a single case of ovarian cancer, these are potentially preventable through population screening but not through screening of established ovarian cancer families.<\/jats:p>","DOI":"10.1111\/cge.12548","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T23:33:16Z","timestamp":1417649596000},"page":"303-312","source":"Crossref","is-referenced-by-count":37,"title":["Genetic testing for <i>RAD51C<\/i> mutations: in the clinic and community"],"prefix":"10.1111","volume":"88","author":[{"given":"V.","family":"Sopik","sequence":"first","affiliation":[{"name":"Women's College Research Institute, Women's College Hospital University of Toronto  Toronto Ontario M5G 1N8 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.R.","family":"Akbari","sequence":"additional","affiliation":[{"name":"Women's College Research Institute, 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