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The objective of this study was to measure the prevalence of depressive symptoms among a large sample of adults with\n NF1<\/jats:styled-content>\n and to quantify the impact of depressive symptoms on quality of life (\n QoL<\/jats:styled-content>\n ). This cross\u2010sectional study used an Internet\u2010based questionnaire to collect data from 498 adults who self\u2010reported as having\n NF1<\/jats:styled-content>\n . Using the Center for Epidemiologic Studies Depression (CESD) scale, 55% of all participants (61% of females and 43% of males) scored above 16, indicating a high likelihood of clinical depression. In a multivariate regression model controlling for demographics and potential confounders, depressive symptoms accounted for 32% of the variance in\n QoL<\/jats:styled-content>\n as measured by the Quality of Life Index. This study is the largest to date and found the highest prevalence of depression compared to prior studies. Our data provide more compelling evidence that individuals with\n NF1<\/jats:styled-content>\n are at increased risk for psychiatric morbidity and suggest that this population should be routinely screened for depression. Because depression was found to be strongly associated with\n QoL<\/jats:styled-content>\n and accounted for nearly one\u2010third of the variance in\n QoL<\/jats:styled-content>\n , it is likely that effectively treating depression may significantly enhance\n QoL<\/jats:styled-content>\n for individuals with\n NF1<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/cge.12551","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T01:06:02Z","timestamp":1419296762000},"page":"425-430","source":"Crossref","is-referenced-by-count":83,"title":["Depression among adults with neurofibromatosis type 1: prevalence and impact on quality of life"],"prefix":"10.1111","volume":"88","author":[{"given":"J.S.","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Neurology and Developmental Medicine Kennedy Krieger Institute Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.P.","family":"Levy","sequence":"additional","affiliation":[{"name":"McKusick Nathans Institute of Genetic Medicine and Division of General Internal Medicine Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sloan","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dariotis","sequence":"additional","affiliation":[{"name":"Department of Population, Family, and Reproductive Health Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"},{"name":"College of Education, Criminal Justice, and Human Services University of Cincinnati Cincinnati MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.B.","family":"Biesecker","sequence":"additional","affiliation":[{"name":"Social and Behavioral Research Branch National Human Genome Research Institute, National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-007-9101-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2006.045906"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-5050(02)00543-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.30.7.567"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.04.025"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.03.005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31422"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-139X(03)00530-5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.137.11.1421"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337548"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2012.85"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.1.103"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(98)00052-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.23.3095"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000187594"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.08.045"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08949.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/975364"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.135.9.1036"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.137.9.1081"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/nur.4770150106"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33380"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20127"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2002.620203.x"},{"key":"e_1_2_6_27_1","unstructured":"FerransCE. 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