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The goal of genetic screening is to identify individuals at increased risk for treatable diseases. The evolution of genetic testing to include multi\u2010disease panels allows for new screening applications which challenge the traditional model of clinical genetics care by the identification of late\u2010onset disorders in an asymptomatic fetus, child, or adult. We present two unique examples of individuals referred to a biochemical genetics clinic due to the detection of late\u2010onset Pompe disease by population\u2010based screening modalities. 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