{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T06:05:16Z","timestamp":1762409116163},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,31]],"date-time":"2015-05-31T00:00:00Z","timestamp":1433030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Bahamas Breast Cancer Initiative Foundation"},{"name":"Komen","award":["SG09-00001"],"award-info":[{"award-number":["SG09-00001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Population\u2010based testing for <jats:italic><jats:styled-content style=\"fixed-case\">BRCA1<\/jats:styled-content>\/2<\/jats:italic> mutations detects a high proportion of carriers not identified by cancer family history\u2010based testing. We sought to determine whether population\u2010based testing is an effective approach to genetic testing in the Bahamas, where 23% of women with breast cancer carry one of seven founder mutations in the <jats:italic><jats:styled-content style=\"fixed-case\">BRCA1<\/jats:styled-content><\/jats:italic> or <jats:italic><jats:styled-content style=\"fixed-case\">BRCA2<\/jats:styled-content><\/jats:italic> gene. We determined the prevalence of founder <jats:italic><jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content><\/jats:italic> mutations in 1847 Bahamian women without a personal history of breast or ovarian cancer, unselected for age or family history. We found that 2.8% (20\/705) of unaffected women with a family history of breast\/ovarian cancer and 0.09% (1\/1089) of unaffected women without a family history carry a <jats:italic><jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content><\/jats:italic> mutation. A total of 38% of unaffected women with a known mutation in the family were found to carry the familial mutation. We previously suggested that all Bahamian women with breast or ovarian cancer be offered genetic testing. These current data suggest that additionally all unaffected Bahamian women with a family history of breast\/ovarian cancer should be offered genetic testing for the founder <jats:italic><jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content><\/jats:italic> mutations.<\/jats:p>","DOI":"10.1111\/cge.12602","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T09:59:57Z","timestamp":1430301597000},"page":"328-331","source":"Crossref","is-referenced-by-count":22,"title":["Prevalence of founder mutations in the <scp>BRCA1<\/scp> and <scp>BRCA2<\/scp> genes among unaffected women from the Bahamas"],"prefix":"10.1111","volume":"89","author":[{"given":"M.","family":"Trottier","sequence":"first","affiliation":[{"name":"Bahamas Breast Cancer Initiative Foundation  Nassau Bahamas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lunn","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Doctors Hospital  Nassau Bahamas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Oncology Princess Margaret Hospital  Nassau Bahamas"},{"name":"Department of Obstetrics and Gynecology Princess Margaret Hospital  Nassau Bahamas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Curling","sequence":"additional","affiliation":[{"name":"Department of Oncology Princess Margaret Hospital  Nassau Bahamas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Turnquest","sequence":"additional","affiliation":[{"name":"Department of Oncology Princess Margaret Hospital  Nassau Bahamas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Oncology Princess Margaret Hospital  Nassau Bahamas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Halliday","sequence":"additional","affiliation":[{"name":"Department of Oncology Princess Margaret Hospital  Nassau Bahamas"},{"name":"Department of Obstetrics and Gynecology Princess Margaret Hospital  Nassau Bahamas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Royer","sequence":"additional","affiliation":[{"name":"Women's College Research Institute Women's College Hospital  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Women's College Research Institute Women's College Hospital  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Li","sequence":"additional","affiliation":[{"name":"Women's College Research Institute Women's College Hospital  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Bahamas Breast Cancer Initiative Foundation  Nassau Bahamas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Donenberg","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center University of Miami  Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hurley","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center University of Miami  Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Akbari","sequence":"additional","affiliation":[{"name":"Women's College Research Institute Women's College Hospital  Toronto Ontario Canada"},{"name":"Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A.","family":"Narod","sequence":"additional","affiliation":[{"name":"Women's College Research Institute Women's College Hospital  Toronto Ontario Canada"},{"name":"Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-1156-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12132"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1095-198"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1096-188"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1096-185"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.14.1241"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.8.611"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.0712"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1941-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.309"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1415979111"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.23.2587"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12468"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/07357900701359841"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcge.12602","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cge.12602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:10:37Z","timestamp":1696331437000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cge.12602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,31]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/cge.12602"],"URL":"https:\/\/doi.org\/10.1111\/cge.12602","archive":["Portico"],"relation":{},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,31]]}}}