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Dopamine imbalance has previously been shown in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>, and furthermore dopamine is thought to be implicated in cognition, behavioral and motor disturbances. A substantiated inverse correlation between motor onset and the elongated <jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content> repeat in the <jats:italic><jats:styled-content style=\"fixed-case\">HTT<\/jats:styled-content><\/jats:italic> has been established. This relation does not account for the full variability of the motor onset, and efforts have been put into finding genetic modifiers of motor onset, however, mostly with unsuccessful outcome. In this study, we took an alternative approach focusing on symptom complexes and searched for modifiers of cognitive impairment and psychiatric symptoms in a well\u2010described cohort of Danish <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> gene\u2010expansion carriers. We show that cognitive impairment and psychiatric symptoms in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> are modified by polymorphisms in the monoamine oxidase A (<jats:italic><jats:styled-content style=\"fixed-case\">MAOA<\/jats:styled-content><\/jats:italic>) and catechol\u2010<jats:italic>O<\/jats:italic>\u2010methyltransferase (<jats:italic><jats:styled-content style=\"fixed-case\">COMT<\/jats:styled-content><\/jats:italic>) genes and by the 4p16.3 B haplotype. These results support the theory of dopamine imbalance in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>, and point toward more personalized treatment modalities of <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> in the future.<\/jats:p>","DOI":"10.1111\/cge.12628","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T06:50:49Z","timestamp":1434523849000},"page":"320-327","source":"Crossref","is-referenced-by-count":13,"title":["Psychiatric and cognitive symptoms in Huntington's disease are modified by polymorphisms in catecholamine regulating enzyme genes"],"prefix":"10.1111","volume":"89","author":[{"given":"T.","family":"Vinther\u2010Jensen","sequence":"first","affiliation":[{"name":"Neurogenetics Clinic, Danish Dementia Research Centre, Department of Neurology, Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Cellular and Molecular Medicine, Section of Neurogenetics 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