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Case series, cross\u2010sectional, case\u2013control, and prospective studies were included. From 534 communications, 47 were eligible. Population\u2010based studies were not found; minimal prevalence of 0.5\u20134\/100,000 was estimated for Venezuela and Mexico. Geographical isolates were well characterized in Venezuela and in Peru.<jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content>repeats at<jats:italic><jats:styled-content style=\"fixed-case\">HTT<\/jats:styled-content><\/jats:italic>gene varied between 7\u201333 and 37\u2013112 in normal and expanded alleles, respectively. Intermediate alleles were found in 4\u201310% of controls. Ages at onset and the expanded<jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content>repeats correlated with<jats:italic>r<\/jats:italic>from \u2013 0.55 to \u20130.91. While haplotype patterns of Venezuelan and Brazilian chromosomes were similar to those observed in Europeans, haplotypes from Peruvian<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>patients did not match the same pattern. The limited number of papers found suggests that<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>is poorly diagnosed in<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>. Minimal prevalence seemed to be halfway between those of Caucasians and Asians. Range of<jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content>repeats was similar to those of Europeans. Haplotype studies indicate that majority of<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>patients might be of Caucasian descent; an Asian origin for some Peruvian patients was proposed.<\/jats:p>","DOI":"10.1111\/cge.12641","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T15:02:35Z","timestamp":1436886155000},"page":"295-303","source":"Crossref","is-referenced-by-count":20,"title":["Genetic aspects of Huntington's disease in Latin America. 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