{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:21:19Z","timestamp":1789885279594,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>Microarray\u2010based comparative genomic hybridization (<jats:styled-content style=\"fixed-case\">aCGH<\/jats:styled-content>) is commonly used in diagnosing patients with intellectual disability (<jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>) with or without congenital malformation. Because <jats:styled-content style=\"fixed-case\">aCGH<\/jats:styled-content> interrogates with the whole genome, there is a risk of being confronted with incidental findings (<jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content>). In order to anticipate the ethical issues of <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content> with the generalization of new genome\u2010wide analysis technologies, we questioned French clinicians and cytogeneticists about the situations they have faced regarding <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">aCGH<\/jats:styled-content>. Sixty\u2010five <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content> were reported. Forty corresponded to autosomal dominant diseases with incomplete penetrance, 7 to autosomal dominant diseases with complete penetrance, 14 to X\u2010linked diseases, and 4 were heterozygotes for autosomal recessive diseases with a high prevalence of heterozygotes in the population. Therapeutic\/preventive measures or genetic counselling could be argued for all cases except four. These four <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content> were intentionally not returned to the patients. Clinicians reported difficulties in returning the results in 29% of the cases, mainly when the question of <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content> had not been anticipated. Indeed, at the time of the investigation, only 48% of the clinicians used consents mentioning the risk of <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content>. With the emergence of new technologies, there is a need to report such national experiences; they show the importance of pre\u2010test information on <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cge.12696","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T05:48:46Z","timestamp":1447912126000},"page":"630-635","source":"Crossref","is-referenced-by-count":11,"title":["Genetic counselling difficulties and ethical implications of incidental findings from array\u2010CGH: a 7\u2010year national survey"],"prefix":"10.1111","volume":"89","author":[{"given":"M.","family":"Lefebvre","sequence":"first","affiliation":[{"name":"Centre de G\u00e9n\u00e9tique et Centre de R\u00e9f\u00e9rence Anomalies du D\u00e9veloppement et Syndromes Malformatifs de l'Est FHU\u2010TRANSLAD  Dijon France"},{"name":"G\u00e9n\u00e9tique des Anomalies du D\u00e9veloppement Universit\u00e9 de Bourgogne  Dijon 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