{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:35:43Z","timestamp":1791333343412,"version":"4.3.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T00:00:00Z","timestamp":1452211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"PHRC National Bardet Biedl 2007","award":["IDRCB 2007-A00868-45"],"award-info":[{"award-number":["IDRCB 2007-A00868-45"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2016,7]]},"abstract":"Olfactory bulb (OB<\/jats:styled-content>) volume evaluation by magnetic resonance imaging (MRI<\/jats:styled-content>) has been demonstrated to be related to olfactory dysfunction in many different diseases. Olfactory dysfunction is often overlooked in Bardet\u2212Biedl syndrome (BBS<\/jats:styled-content>) patients and is rarely objectively evaluated by MRI<\/jats:styled-content>. We present a series of 20 BBS<\/jats:styled-content> patients with olfactory dysfunction. The OB was evaluated separately and blindly by two radiologists (SR<\/jats:styled-content> and SM<\/jats:styled-content>) with 3 Tesla MRI<\/jats:styled-content> imaging comparatively to 12 normal control subjects by global visual evaluation and by quantitative measurement of OB<\/jats:styled-content> volume. In the 12 control cases OB<\/jats:styled-content> visual evaluation was considered as normal in all cases for radiologist (SR<\/jats:styled-content>) and in 10 cases for radiologist (SM<\/jats:styled-content>). In the 20 BBS<\/jats:styled-content> patients, OB<\/jats:styled-content> visual evaluation was considered as abnormal in 18 cases for SR<\/jats:styled-content> and in all cases for SM<\/jats:styled-content>. OB<\/jats:styled-content> volumetric evaluation for SR<\/jats:styled-content> and SM<\/jats:styled-content> in BBS<\/jats:styled-content> patients was able to provide significant correlation between BBS<\/jats:styled-content> and olfactory dysfunction. This study indicates that OB<\/jats:styled-content> volume evaluation by MRI<\/jats:styled-content> imaging like structural MRI<\/jats:styled-content> scan for gray matter modifications demonstrates that olfactory dysfunction in BBS<\/jats:styled-content> patients is a constant and cardinal symptom integrated in a genetical syndrome with peripheral and central olfactory structure alterations.<\/jats:p>","DOI":"10.1111\/cge.12697","type":"journal-article","created":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T06:52:44Z","timestamp":1448002364000},"page":"79-83","source":"Crossref","is-referenced-by-count":18,"title":["Value of MRI<\/scp> olfactory bulb evaluation in the assessment of olfactory dysfunction in Bardet\u2013Biedl syndrome"],"prefix":"10.1111","volume":"90","author":[{"given":"J.J.","family":"Braun","sequence":"first","affiliation":[{"name":"Service ORL\u2010CCF H\u00f4pitaux Universitaires de Strasbourg Strasbourg 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