{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T20:56:19Z","timestamp":1781902579303,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,4]],"date-time":"2016-03-04T00:00:00Z","timestamp":1457049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Developmental dysplasia of the hip (<jats:styled-content style=\"fixed-case\">DDH<\/jats:styled-content>) is one of the most common skeletal anomalies. <jats:styled-content style=\"fixed-case\">DDH<\/jats:styled-content> encompasses a spectrum of the disorder ranging from minor acetabular dysplasia to irreducible dislocation, which may lead to premature arthritis in later life. Involvement of genetic factors underlying <jats:styled-content style=\"fixed-case\">DDH<\/jats:styled-content> became evident when several studies reported chromosomal loci linked to <jats:styled-content style=\"fixed-case\">DDH<\/jats:styled-content> in families with multiple affected individuals. Moreover, using association studies, variants in genes involved in chondrogenesis and joint formation have been shown to be associated with <jats:styled-content style=\"fixed-case\">DDH<\/jats:styled-content>. At least, one study identified a pathogenic variant in the chemokine receptor gene in <jats:styled-content style=\"fixed-case\">DDH<\/jats:styled-content>. No genetic analysis has been reported or carried out in <jats:styled-content style=\"fixed-case\">DDH<\/jats:styled-content> patients from the Middle East. Here, we review the literature related to genetics of <jats:styled-content style=\"fixed-case\">DDH<\/jats:styled-content> and emphasized the usefulness of new generation technologies in identifying genetic variants underlying <jats:styled-content style=\"fixed-case\">DDH<\/jats:styled-content> in consanguineous families.<\/jats:p>","DOI":"10.1111\/cge.12755","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T06:22:08Z","timestamp":1454566928000},"page":"16-20","source":"Crossref","is-referenced-by-count":20,"title":["Developmental dysplasia of the hip: usefulness of next generation genomic tools for characterizing the underlying genes \u2013 a mini review"],"prefix":"10.1111","volume":"90","author":[{"given":"S.","family":"Basit","sequence":"first","affiliation":[{"name":"Centre for Genetics and Inherited Diseases  Almadinah Almunawwarah Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Hannan","sequence":"additional","affiliation":[{"name":"Centre for Genetics and Inherited Diseases  Almadinah Almunawwarah Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. I.","family":"Khoshhal","sequence":"additional","affiliation":[{"name":"College of Medicine Taibah University  Almadinah Almunawwarah Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1999"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016470510030517"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320360403"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199912000-00014"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/505088"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3944\/AOTT.2008.289"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-1073-6"},{"key":"e_1_2_7_9_1","first-page":"430","article-title":"Congenital hip disease in Utah: the influence of genetic and nongenetic factors","volume":"20","author":"Woolf CM","year":"1968","journal-title":"Am J Hum Genet"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.12.2.125"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90013-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00003086-199208000-00013","article-title":"Etiologic factors in congenital displacement of the hip and myelodysplasia","volume":"281","author":"Wilkinson JA","year":"1992","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_7_13_1","first-page":"106","article-title":"The importance of predicted risk factors in developmental hip dysplasia: an ultrasonographic screening program","volume":"36","author":"Karapinar L","year":"2002","journal-title":"Acta Orthop Traumatol Turc"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.1.93"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-008-0120-z"},{"key":"e_1_2_7_16_1","first-page":"218","article-title":"Incidence and pattern of congenital dislocation of the hip in Aseer region of Saudi Arabia","volume":"21","author":"Mirdad T","year":"2002","journal-title":"West Afr J Med"},{"key":"e_1_2_7_17_1","first-page":"1118","article-title":"The pattern of developmental dysplasia of the hip","volume":"24","author":"Kremli MK","year":"2003","journal-title":"Saudi Med J"},{"key":"e_1_2_7_18_1","first-page":"952","article-title":"Incidence of developmental dysplasia of the hip in Dubai","volume":"30","author":"Moosa NK1","year":"2009","journal-title":"Saudi Med J"},{"key":"e_1_2_7_19_1","first-page":"620","article-title":"Gene mapping of developmental dysplasia of the hip in chromosome 17q21 region","volume":"27","author":"Li LY","year":"2010","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2540"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.09.008"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3252"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.02.004"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2011.10.016"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1086\/302685"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1839"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.10.004"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-13-59"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22507"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2014.0044"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2012.02682.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0010049"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0598-19"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1149504"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06862"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.091827.109"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.037"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2012.07.005"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.06.014"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12482"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu379"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08250"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq569"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12276"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.05.005"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.76"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2008.02575.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0b013e3181aa586b"},{"key":"e_1_2_7_49_1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/BPO.0b013e31817c4e6d","article-title":"Acetabular cartilaginous angle: a new method for predicting acetabular development in developmental dysplasia of the hip in children between 2 and 18 months of age","volume":"28","author":"Zamzam MM","year":"2008","journal-title":"J Pediatr Orthop"},{"key":"e_1_2_7_50_1","first-page":"19","article-title":"Predective radiographic factors in DDH management","volume":"6","author":"Khoshhal KI","year":"2011","journal-title":"J Taibah Univ Med Sci"},{"key":"e_1_2_7_51_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.5144\/0256-4947.2002.102","article-title":"Evaluation of clinical signs and tests of congenital dysplasia of the hip","volume":"22","author":"Kremli MK","year":"2002","journal-title":"Ann Saudi Med"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJnew.7917"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120212"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-015-2675-0"},{"key":"e_1_2_7_55_1","first-page":"979520","article-title":"A replication study for the association of rs726252 in PAPPA2 with developmental dysplasia of the hip in Chinese Han population","volume":"2014","author":"Shi D","year":"2014","journal-title":"Biomed Res Int"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2013.0179"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcge.12755","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cge.12755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:57:52Z","timestamp":1696316272000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cge.12755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,4]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/cge.12755"],"URL":"https:\/\/doi.org\/10.1111\/cge.12755","archive":["Portico"],"relation":{},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,4]]}}}