{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T02:24:54Z","timestamp":1776047094955,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T00:00:00Z","timestamp":1462492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2016,10]]},"abstract":"The basal transcription of heme oxygenase\u20101 (HO<\/jats:styled-content>\u20101) regulation is dependent upon a GT<\/jats:styled-content> repeat germ line polymorphism (GTn<\/jats:styled-content>) in the promoter of the HO<\/jats:styled-content>\u20101<\/jats:italic> gene. We determined the prognostic value of HO<\/jats:styled-content>\u20101<\/jats:italic> promoter polymorphism on the natural postoperative course of complete resected oesophageal cancer. Genomic DNA<\/jats:styled-content> from 297 patients was amplified by polymerase chain reaction and sequenced. The results were correlated with clinicopathological parameters, disseminated tumour cells in bone marrow (DTC<\/jats:styled-content>) and clinical outcome. Depending on short allele with <25 and long allele with \u226525, GTn<\/jats:styled-content> repeats three genotypes (SS<\/jats:styled-content>, SL<\/jats:styled-content> and LL<\/jats:styled-content>) were defined. A diverse role of GTn<\/jats:styled-content> was evident in squamous cell carcinoma (SCC<\/jats:styled-content>) and adenocarcinoma (AC<\/jats:styled-content>). In SCC<\/jats:styled-content>, the SS<\/jats:styled-content> genotype presented less advanced tumours with lower rate DTC<\/jats:styled-content> in bone marrow and relapse compared with L\u2010allele carriers. In contrast, AC<\/jats:styled-content> patients with the SS<\/jats:styled-content> genotype displayed a complete opposing tumour characteristic. The disease\u2010free (DFS<\/jats:styled-content>) and overall survival (OS<\/jats:styled-content>) in SCC<\/jats:styled-content> patients was markedly reduced in LL<\/jats:styled-content> genotypes (p < 0.001). In AC<\/jats:styled-content> contrarily the SS<\/jats:styled-content> genotype patients displayed the worst DFS<\/jats:styled-content> and OS<\/jats:styled-content> (p < 0.001). GTn<\/jats:styled-content> is a strong prognostic factor with diverse prognostic value for recurrence and survival in AC<\/jats:styled-content> and SCC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cge.12765","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T08:59:13Z","timestamp":1456477153000},"page":"343-350","source":"Crossref","is-referenced-by-count":5,"title":["Diverse prognostic value of the GTn<\/scp> promoter polymorphism in squamous cell and adeno carcinoma of the oesophagus"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1894-9893","authenticated-orcid":false,"given":"T.","family":"Ghadban","sequence":"first","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.T.","family":"Miro","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Trump","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.Y.","family":"Tsui","sequence":"additional","affiliation":[{"name":"Department of Surgery University Medical College Rostock Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.G.","family":"Uzunoglu","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Reeh","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Gebauer","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Wellner","sequence":"additional","affiliation":[{"name":"Clinic for Surgery University Clinic of Schleswig\u2010Holstein, Campus Luebeck Luebeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Kalinin","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Pantel","sequence":"additional","affiliation":[{"name":"Department of Tumor Biology University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.R.","family":"Izbicki","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.K.","family":"Vashist","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-2-35"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2008.0062"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra035010"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg047"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200102000-00011"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21209"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9604-4"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-007-0264-2"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-966655"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181904f3c"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.155861"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1659"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10736"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00046.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207173"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-055723"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690624"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025803600840"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-3875com"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2008.00639.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2009.03221.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/302729"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-004-1162-2"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602186"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9290-7"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21937"},{"key":"e_1_2_5_28_1","first-page":"1142","article-title":"Association of heme oxygenase\u20101 polymorphisms with cancer risk: a systematic review and meta\u2010analysis","volume":"20","author":"Luo H","year":"2015","journal-title":"J BUON"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-012-9371-2"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.11.4617"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2010_01_086"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3125-8"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.035824"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182565b0b"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.04.015"},{"key":"e_1_2_5_36_1","first-page":"929","article-title":"Modulation of EGFR gene transcription by secondary structures, a polymorphic repetitive sequence and mutations \u2013 a link between genetics and epigenetics","volume":"15","author":"Gebhardt F","year":"2000","journal-title":"Histol Histopathol"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0626"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002447"},{"key":"e_1_2_5_39_1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1096\/fj.04-2217fje","article-title":"Heme oxygenase\u20101 modulates the allo\u2010immune response by promoting activation\u2010induced cell death of T cells","volume":"19","author":"McDaid J","year":"2005","journal-title":"FASEB J"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800909789057024"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(03)00128-3"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(98)00372-3"},{"key":"e_1_2_5_43_1","first-page":"355","article-title":"Prediction of radiosensitivity in human esophageal squamous cell carcinomas with heme oxygenase\u20101: a clinicopathological and immunohistochemical study","volume":"8","author":"Yokoyama S","year":"2001","journal-title":"Oncol Rep"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc0252"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.01.0454"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji445"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-10-36"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-012-2254-z"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-2817-7"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcge.12765","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cge.12765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:32:06Z","timestamp":1696368726000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cge.12765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,6]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/cge.12765"],"URL":"https:\/\/doi.org\/10.1111\/cge.12765","archive":["Portico"],"relation":{},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,6]]}}}