{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:17:50Z","timestamp":1791299870527,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T00:00:00Z","timestamp":1471824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Identifying women at risk of venous thrombosis (VT<\/jats:styled-content>) under combined oral contraceptives (COC<\/jats:styled-content>) is a major public health issue. The aim of this study was to investigate in COC<\/jats:styled-content> users the impact on disease of genetic polymorphisms recently identified to associate with VT<\/jats:styled-content> risk in the general population. Nine polymorphisms located on KNG1<\/jats:italic>, F11<\/jats:italic>, F5<\/jats:italic>, F2<\/jats:italic>, PROCR<\/jats:italic>, FGG<\/jats:italic>, TSPAN<\/jats:italic> and SLC44A2<\/jats:styled-content><\/jats:italic> genes were genotyped in a sample of 766 patients and 464 controls as part of the PILGRIM<\/jats:styled-content> (PILl Genetic Risk Monitoring) study. Cases were women who experienced an episode of documented VT<\/jats:styled-content> during COC<\/jats:styled-content> use, while controls were women with no history of VT<\/jats:styled-content> using COC<\/jats:styled-content> at the time of inclusion. Among the studied polymorphisms, only F11<\/jats:italic> rs2289252 was significantly associated with VT<\/jats:styled-content>. The F11<\/jats:italic> rs2289252\u2010A allele was associated with a 1.6\u2010fold increased risk of VT<\/jats:styled-content> (p < 0.0001). Besides, the combination of the rs2289252\u2010A allele with non\u2010O blood group, present in 52% of the cohort, was associated with an odds ratio of 4.00 (2.49\u20136.47; p < 10\u22124<\/jats:sup>). The consideration of this genetic risk factor could help to better assess the risk of VT<\/jats:styled-content> in COC<\/jats:styled-content> users.<\/jats:p>","DOI":"10.1111\/cge.12833","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T14:17:09Z","timestamp":1468505829000},"page":"131-136","source":"Crossref","is-referenced-by-count":8,"title":["Genetic risk factors for venous thrombosis in women using combined oral contraceptives: update of the PILGRIM<\/scp> study"],"prefix":"10.1111","volume":"91","author":[{"given":"P.","family":"Suchon","sequence":"first","affiliation":[{"name":"AIx Marseille Univ, INSERM INRA, NORT Marseille France"},{"name":"APHM, H\u00f4pital de la Timone Service d'h\u00e9matologie biologique Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Al Frouh","sequence":"additional","affiliation":[{"name":"APHM, H\u00f4pital de la Timone Service d'h\u00e9matologie biologique Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"AIx Marseille Univ, INSERM INRA, NORT Marseille France"},{"name":"APHM, H\u00f4pital de la Timone Service d'h\u00e9matologie biologique Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sarlon","sequence":"additional","affiliation":[{"name":"M\u00e9decine vasculaire et Hypertension art\u00e9rielle, Facult\u00e9 de M\u00e9decine de Marseille, Aix\u2010Marseille Universit\u00e9 Assistance Publique H\u00f4pitaux de Marseille \u2013 H\u00f4pital de La Timone Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Venton","sequence":"additional","affiliation":[{"name":"INSERM, UMR1090 TAGC Aix\u2010Marseille University Marseille France"},{"name":"Service d'h\u00e9matologie, APHM, H\u00f4pital de la Conception Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010C.","family":"Alessi","sequence":"additional","affiliation":[{"name":"AIx Marseille Univ, INSERM INRA, NORT Marseille France"},{"name":"APHM, H\u00f4pital de la Timone Service d'h\u00e9matologie biologique Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.\u2010A.","family":"Tr\u00e9gou\u00ebt","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06 INSERM UMR_S 1166 Paris France"},{"name":"ICAN Institute for Cardiometabolism and Nutrition Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.\u2010E.","family":"Morange","sequence":"additional","affiliation":[{"name":"AIx Marseille Univ, INSERM INRA, NORT Marseille France"},{"name":"APHM, H\u00f4pital de la Timone Service d'h\u00e9matologie biologique Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-09-0793"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f5298"},{"key":"e_1_2_6_4_1","unstructured":"United Nations. 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