{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:45:48Z","timestamp":1776872748519,"version":"3.51.2"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T00:00:00Z","timestamp":1480464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>Gestational diabetes mellitus (<jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>) is a metabolic disorder that occurs during pregnancy. <jats:italic><jats:styled-content style=\"fixed-case\">HHEX<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">PROX1<\/jats:styled-content><\/jats:italic> are genetic loci associated with diabetes mellitus type 2. <jats:italic><jats:styled-content style=\"fixed-case\">HHEX<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">PROX1<\/jats:styled-content><\/jats:italic> play significant roles in carbohydrate intolerance and diabetes because these transcription factors may be involved in the regulation of insulin secretion and in glucose and lipid metabolism. The aim of this study was to examine the association between <jats:italic><jats:styled-content style=\"fixed-case\">HHEX<\/jats:styled-content><\/jats:italic> (rs5015480) and <jats:italic><jats:styled-content style=\"fixed-case\">PROX1<\/jats:styled-content><\/jats:italic> (rs340874) gene polymorphisms and <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>. This study included 204 pregnant women with <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> and 207 pregnant women with the normal glucose tolerance (<jats:styled-content style=\"fixed-case\">NGT<\/jats:styled-content>). The diagnosis of <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> was based on a 75\u2010g oral glucose tolerance test at 24\u201328 weeks' gestation. There was a statistically significant prevalence of the <jats:italic><jats:styled-content style=\"fixed-case\">HHEX<\/jats:styled-content><\/jats:italic> rs5015480 <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> genotype and C allele among women with <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> (C vs T allele, p\u2009=\u20090.021, odds ratio <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20091.40, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.05\u20131.87). Statistically significant higher increase of body mass and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> during pregnancy was found in women with the <jats:italic><jats:styled-content style=\"fixed-case\">HHEX<\/jats:styled-content><\/jats:italic> rs5015480 <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> genotype. The results of our study suggest an association between the <jats:italic><jats:styled-content style=\"fixed-case\">HHEX<\/jats:styled-content><\/jats:italic> gene rs5015480 polymorphism and risk of <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>. The <jats:italic><jats:styled-content style=\"fixed-case\">HHEX<\/jats:styled-content><\/jats:italic> gene rs5015480 C allele may be a risk allele of <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> that is associated with increased <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> during pregnancy.<\/jats:p>","DOI":"10.1111\/cge.12875","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T17:37:51Z","timestamp":1475170671000},"page":"843-848","source":"Crossref","is-referenced-by-count":11,"title":["Hematopoietically expressed homeobox (<i>HHEX<\/i>) gene polymorphism (rs5015480) is associated with increased risk of gestational diabetes mellitus"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3869-5077","authenticated-orcid":false,"given":"M.","family":"Tarnowski","sequence":"first","affiliation":[{"name":"Department of Physiology Pomeranian Medical University  Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Malinowski","sequence":"additional","affiliation":[{"name":"Department of Physiology Pomeranian Medical University  Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Safranow","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Chemistry Pomeranian Medical University  Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Dziedziejko","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Chemistry Pomeranian Medical University  Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Czerewaty","sequence":"additional","affiliation":[{"name":"Department of Physiology Pomeranian Medical University  Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pawlik","sequence":"additional","affiliation":[{"name":"Department of Physiology Pomeranian Medical University  Szczecin 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