{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:06:41Z","timestamp":1745460401198},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T00:00:00Z","timestamp":1488931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003921","name":"Department of Health, Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>As Newfoundland has the highest rate of familial colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>) in the world, we started a population\u2010based clinic to provide colonoscopic and Lynch syndrome (<jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>) screening recommendations to families of <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> patients based on family risk. Of 1091 incident patients 51% provided a family history. Seventy\u2010two percent of families were at low or intermediate\u2013low risk of <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> and colonoscopic screening recommendations were provided by letter. Twenty\u2010eight percent were at high and intermediate\u2013high risk and were referred to the genetic counsellor, but only 30% (<jats:italic>N<\/jats:italic>\u2009=\u200948) were interviewed by study end. Colonoscopy was recommended more frequently than every 5 years in 35% of families. Lower family risk was associated with older age of proband but the frequency of screening colonoscopy recommendations varied across all age groups, driven by variability in family history. Twenty\u2010four percent had a high <jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content> predict score for a Lynch syndrome mutation, and 23% fulfilled the Provincial Program criteria for <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> screening. A population\u2010based approach in the provision of colonoscopic screening recommendations to families at risk of <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> was limited by the relatively low response rate. A family history first approach to the identification of <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> families was inefficient.<\/jats:p>","DOI":"10.1111\/cge.12877","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T18:36:29Z","timestamp":1476210989000},"page":"672-682","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of a population\u2010based approach to familial colorectal cancer"],"prefix":"10.1111","volume":"91","author":[{"given":"P.S.","family":"Parfrey","sequence":"first","affiliation":[{"name":"The Clinical Epidemiology Unit Memorial University  St Johns Newfoundland Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Dicks","sequence":"additional","affiliation":[{"name":"The Clinical Epidemiology Unit Memorial University  St Johns Newfoundland Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Parfrey","sequence":"additional","affiliation":[{"name":"The Clinical Epidemiology Unit Memorial University  St Johns Newfoundland Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.J.","family":"McNicholas","sequence":"additional","affiliation":[{"name":"The Clinical Epidemiology Unit Memorial University  St Johns Newfoundland Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Noseworthy","sequence":"additional","affiliation":[{"name":"The Clinical Epidemiology Unit Memorial University  St Johns Newfoundland Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.O.","family":"Woods","sequence":"additional","affiliation":[{"name":"The Clinical Epidemiology Unit Memorial University  St Johns Newfoundland Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Negriin","sequence":"additional","affiliation":[{"name":"The Clinical Epidemiology Unit Memorial University  St Johns Newfoundland Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Green","sequence":"additional","affiliation":[{"name":"Discipline of Genetics, Health Sciences Centre Memorial University  St Johns Newfoundland Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,8]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Canadian Cancer Statistics 2015","author":"Canadian Cancer Society's Advisory Committee on Cancer Statistics","year":"2015"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-006-9104-x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15-1677"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28397"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.217091"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70510-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.16.1979"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12080"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0726"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-009-9291-3"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-006-0014-8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2011.01802.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1897-4287-9-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh034"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hcmf.2010.07.001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009506"},{"key":"e_1_2_6_19_1","unstructured":"MMR Predict Calculator. University of Edinburg and MRC Human Genetics Unit Edinburgh Scotland.http\/\/hnpccpredict.hgu.mrc.ac.uk\/2014."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370010303"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn499"},{"issue":"10","key":"e_1_2_6_22_1","first-page":"1","article-title":"Fecal occult blood test for colorectal cancer screening: an evidence based analysis","volume":"9","author":"Health Quality Ontario","year":"2009","journal-title":"Ont Health Technol Assess Ser"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001352"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38606.794560.EB"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-11-0229"},{"key":"e_1_2_6_26_1","unstructured":"National Comprehensive Cancer Network NCCN. Clinical Practice Guidelines in Oncology. Genetic\/Familial High\u2010risk Assessment: Colorectal. Version 1 NCCN Org 2016."},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-261"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e31818fa2ff"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.13088"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s0022-016-1832-7"},{"key":"e_1_2_6_31_1","first-page":"81","article-title":"Ontario familial colon cancer registry: methods and first\u2010year response rates","volume":"21","author":"Cotterchio M","year":"2000","journal-title":"Chronic Dis Can"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02573873"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcge.12877","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcge.12877","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cge.12877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:24:31Z","timestamp":1696245871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cge.12877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,8]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/cge.12877"],"URL":"https:\/\/doi.org\/10.1111\/cge.12877","archive":["Portico"],"relation":{},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,8]]}}}