{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:24:03Z","timestamp":1790234643630,"version":"4.1.0"},"reference-count":137,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T00:00:00Z","timestamp":1480464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>Endometriosis is a gynecologic disease affecting up to 10% of the women and a major cause of pain and infertility. It is characterized by the implantation of functional endometrial tissue at ectopic positions generally within the peritoneum. This complex disease has an important genetic component with a heritability estimated at around 50%. This review aims at providing recent insights into the genetic bases of endometriosis, and presents a detailed overview of evidence of epigenetic alterations specific to this disease. In the future, these alterations may constitute therapeutic targets for pharmacological compounds able to modify the epigenetic code.<\/jats:p>","DOI":"10.1111\/cge.12897","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T03:43:59Z","timestamp":1476762239000},"page":"254-264","source":"Crossref","is-referenced-by-count":126,"title":["Recent insights on the genetics and epigenetics of endometriosis"],"prefix":"10.1111","volume":"91","author":[{"given":"B.","family":"Borghese","sequence":"first","affiliation":[{"name":"Cochin Institute, U1016 INSERM, CNRS 8104 Universit\u00e9 Paris Descartes  Paris France"},{"name":"Department of Gynecology Obstetrics II and Reproductive Medicine, Facult\u00e9 de M\u00e9decine, AP\u2010HP, Groupe Hospitalier Ouest Centre Hospitalier Universitaire Paris Centre  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.T.","family":"Zondervan","sequence":"additional","affiliation":[{"name":"Nuffield Department of Obstetrics and Gynaecology, Endometriosis Care Centre University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.S.","family":"Abrao","sequence":"additional","affiliation":[{"name":"Endometriosis Division, Obstetrics and Gynecology Department Sao Paulo University  Sao Paulo Brazil"},{"name":"Reproductive Clinic Sirio Libanes Hospital  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Chapron","sequence":"additional","affiliation":[{"name":"Cochin Institute, U1016 INSERM, CNRS 8104 Universit\u00e9 Paris Descartes  Paris France"},{"name":"Department of Gynecology Obstetrics II and Reproductive Medicine, Facult\u00e9 de M\u00e9decine, AP\u2010HP, Groupe Hospitalier Ouest Centre Hospitalier Universitaire Paris Centre  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Vaiman","sequence":"additional","affiliation":[{"name":"Cochin Institute, U1016 INSERM, CNRS 8104 Universit\u00e9 Paris Descartes  Paris France"},{"name":"Department of Gynecology Obstetrics II and Reproductive Medicine, Facult\u00e9 de M\u00e9decine, AP\u2010HP, Groupe Hospitalier Ouest Centre Hospitalier Universitaire Paris Centre  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17403-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.02.102"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del339"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-8-194"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(15)30003-X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1000274"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.255"},{"key":"e_1_2_6_9_1","first-page":"745","article-title":"Uber den staude der frage der adenomyosites adenomyoma in allgemeinen und adenomyonetitis sarcomatosa","volume":"36","author":"Meyer R","year":"1919","journal-title":"Zentralbl Gynakol"},{"key":"e_1_2_6_10_1","first-page":"413","article-title":"Mullerianosis","volume":"323","author":"Batt RE","year":"1990","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.029"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2357-8"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/795976"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.05969.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)00191-X"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg009"},{"key":"e_1_2_6_17_1","first-page":"734","article-title":"Diagnosis and treatment of endometriosis. A review","volume":"25","author":"Scarselli G","year":"2009","journal-title":"Gynecol Endocrinol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg136"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.09.005"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.07.1061"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2305-0500(14)60039-7"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2009.01030.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60490-4"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-010-9436-1"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-015-0196-z"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(98)00540-8"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.06.035"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13669-012-0016-5"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.2217\/whe.15.41"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03341-1"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1086\/432960"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del446"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2010.118"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.612"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.731"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2445"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058257"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.07.1208"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1585408"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu015"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2015.61"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3242"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11582"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/17068"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.685"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu516"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi.12.18"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.07.709"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.07.1209"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.07.1244"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719111415546"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2010.08.003"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.03.022"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2012.01.002"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10008"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014033108"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2016.02.002"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0160"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004158"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1554053"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.01.034"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12236"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu161"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gam005"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2010.09.012"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-10-1"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2008-0322"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113199990517"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.12.008"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.08.008"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.154"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-016-0222-5"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.05.008"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950170510"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1998.4027"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der203"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719113497267"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719111432870"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719113488450"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2591-0"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den007"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des446"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703451104"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005893"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2015.2263"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-016-0727-z"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1507931112"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0289"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1159\/000093975"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1606"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63030-1"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.10.6988"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719107302913"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.04.012"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.115.138115"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12155"},{"key":"e_1_2_6_97_1","first-page":"1094","article-title":"Experimental endometriosis: a microsurgical animal model in rats","volume":"20","author":"Golan A","year":"1984","journal-title":"Isr J Med Sci"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719110381928"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719111424453"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep472"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.040675"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80837-5"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403663101"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.11.033"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.03.009"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp034"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu019"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.081059"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730413476827"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022586"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.06.029"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.08.036"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1450"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3717"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3010"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.11.055"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2013.1536"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4295"},{"key":"e_1_2_6_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201100200"},{"key":"e_1_2_6_120_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des329"},{"key":"e_1_2_6_121_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201505245"},{"key":"e_1_2_6_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.05.020"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu332"},{"key":"e_1_2_6_124_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719116650758"},{"key":"e_1_2_6_125_1","first-page":"35","article-title":"Clinical use and applications of histone deacetylase inhibitors in multiple myeloma","volume":"8","author":"Tandon N","year":"2016","journal-title":"Clin Pharmacol"},{"key":"e_1_2_6_126_1","article-title":"Microarray analysis of microRNA deregulation and angiogenesis\u2010related proteins in endometriosis","volume":"15","author":"Yang RQ","year":"2016","journal-title":"Genet Mol Res"},{"key":"e_1_2_6_127_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/760698"},{"key":"e_1_2_6_128_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-11-78"},{"key":"e_1_2_6_129_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der025"},{"key":"e_1_2_6_130_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0371"},{"key":"e_1_2_6_131_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/369549"},{"key":"e_1_2_6_132_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2008-0387"},{"key":"e_1_2_6_133_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gap068"},{"key":"e_1_2_6_134_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719116641761"},{"key":"e_1_2_6_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.04.013"},{"key":"e_1_2_6_136_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2726"},{"key":"e_1_2_6_137_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2415"},{"key":"e_1_2_6_138_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des413"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcge.12897","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcge.12897","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cge.12897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T04:05:13Z","timestamp":1694491513000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cge.12897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,30]]},"references-count":137,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/cge.12897"],"URL":"https:\/\/doi.org\/10.1111\/cge.12897","archive":["Portico"],"relation":{},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,30]]}}}