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Hypoglycaemia is common in other overgrowth syndromes but has been described only sporadically in association with PIK3CA and CCND2 variants. We report a cohort of 6 children with megalencephaly\u2010capillary malformation (MCAP) and megalencephaly\u2010polydactyly\u2010polymicrogyria\u2010hydrocephalus (MPPH) syndromes who developed clinically significant hypoglycaemia. Based on our findings, we suggest that segmental overgrowth patients should be screened for low blood glucose levels during childhood and there should be early specialist endocrine review in any children who develop hypoglycaemia.<\/jats:p>","DOI":"10.1111\/cge.13145","type":"journal-article","created":{"date-parts":[[2017,9,23]],"date-time":"2017-09-23T14:16:48Z","timestamp":1506176208000},"page":"687-692","source":"Crossref","is-referenced-by-count":25,"title":["Hypoglycaemia represents a clinically significant manifestation of <i>PIK3CA<\/i>\u2010 and <i>CCND2<\/i>\u2010associated segmental overgrowth"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5220-8837","authenticated-orcid":false,"given":"J.H.","family":"McDermott","sequence":"first","affiliation":[{"name":"Manchester Centre for Genomic Medicine, St Mary's Hospital Central Manchester University Hospitals, NHS Foundation Trust Manchester Academic Health Sciences Centre  Manchester 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