{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T11:19:46Z","timestamp":1768994386615,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>Fusion anomalies of the M\u00fcllerian ducts are associated with an increased risk for miscarriage and premature labor. In most cases polygenic\u2010multifactorial inheritance can be assumed but autosomal\u2010dominant inheritance with reduced penetrance and variable manifestation should be considered. We performed array\u2010comparative genomic hybridization (CGH) analysis in a cohort of 103 patients with M\u00fcllerian fusion anomalies. In 8 patients we detected microdeletions and microduplications in chromosomal regions 17q12, 22q11.21, 9q33.1, 3q26.11 and 7q31.1. The rearrangement in 17q12 including <jats:italic>LHX1<\/jats:italic> and <jats:italic>HNF1\u03b2<\/jats:italic> as well as in 22q11.21 have already been observed in MRKHS (Mayer\u2010Rokitansky\u2010K\u00fcster\u2010Hauser syndrome). In summary, we (1) detected causative micro\u2010rearrangements in patients with M\u00fcllerian fusion anomalies, (2) show that M\u00fcllerian fusion anomalies and MRKHS may have a common etiology, and (3) identified new candidate genes for M\u00fcllerian fusion anomalies.<\/jats:p>","DOI":"10.1111\/cge.13160","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T14:03:04Z","timestamp":1508940184000},"page":"640-646","source":"Crossref","is-referenced-by-count":27,"title":["Array\u2010comparative genomic hybridization analysis in patients with M\u00fcllerian fusion anomalies"],"prefix":"10.1111","volume":"93","author":[{"given":"S.","family":"Ledig","sequence":"first","affiliation":[{"name":"Institute of Human Genetics Westf\u00e4lische Wilhelms\u2010Universit\u00e4t M\u00fcnster (WWU)  M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.C.","family":"Tewes","sequence":"additional","affiliation":[{"name":"Institute 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