{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T20:12:04Z","timestamp":1771963924565,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>The objective of this study was to estimate the lifetime risk of breast cancer in women with a <jats:italic>BRCA1<\/jats:italic> or <jats:italic>BRCA2<\/jats:italic> mutation with and without at least 1 first\u2010degree relative with breast cancer. A total of 2835 women with a <jats:italic>BRCA1<\/jats:italic> or <jats:italic>BRCA2<\/jats:italic> mutation were followed. Age\u2010 and gene\u2010specific breast cancer rates were calculated. The relative risks of breast cancer for subjects with a family history of breast cancer, compared to no family history were calculated. The mean age at baseline was 41.1 years, and they were followed for a mean of 6.0 years. The estimated penetrance of breast cancer to age 80 years was 60.8% for <jats:italic>BRCA1<\/jats:italic> and 63.1% for <jats:italic>BRCA2<\/jats:italic>. For all <jats:italic>BRCA<\/jats:italic> carriers, the penetrance of breast cancer to age 80 for those with no first\u2010degree relative with breast cancer was 60.4% and 63.3% for those with at least 1 first\u2010degree relative with breast cancer. The risk of breast cancer for <jats:italic>BRCA<\/jats:italic> carriers with no first\u2010degree relative with breast cancer is substantial, and as a result, clinical management for these women should be the same as those for women with an affected relative.<\/jats:p>","DOI":"10.1111\/cge.13191","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T16:16:46Z","timestamp":1512490606000},"page":"1063-1068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The risk of breast cancer in <i>BRCA1<\/i> and <i>BRCA2<\/i> mutation carriers without a first\u2010degree relative with breast cancer"],"prefix":"10.1111","volume":"93","author":[{"given":"K.A.","family":"Metcalfe","sequence":"first","affiliation":[{"name":"Lawrence S. Bloomberg Faculty of Nursing University of Toronto  Toronto Canada"},{"name":"Women's College Research Institute Women's College Hospital  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lubinski","sequence":"additional","affiliation":[{"name":"Department of Genetics and Pathology, International Hereditary Cancer Center Pomeranian Medical University  Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Gronwald","sequence":"additional","affiliation":[{"name":"Department of Genetics and Pathology, International Hereditary Cancer Center Pomeranian Medical University  Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Huzarski","sequence":"additional","affiliation":[{"name":"Department of Genetics and Pathology, International Hereditary Cancer Center Pomeranian Medical University  Szczecin 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