{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:56:45Z","timestamp":1792425405699,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GM1513A and D"],"award-info":[{"award-number":["01GM1513A and D"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Temple syndrome (TS14, #616222) is a rare imprinting disorder characterised by phenotypic features including pre\u2010 and postnatal growth retardation, muscular hypotonia and feeding difficulties in infancy, early puberty and short stature with small hands and feet and often truncal obesity. It is caused by maternal uniparental disomies, paternal deletions and primary imprinting defects that affect the chromosomal region 14q32 and lead to a disturbed expression of imprinted genes in this region. Here, we present detailed clinical data of 8 patients with Temple syndrome, 4 with an imprinting defect, 2 with an imprinting defect in a mosaic state as well as 1 complete and 1 segmental maternal uniparental disomy of chromosome 14.<\/jats:p>","DOI":"10.1111\/cge.13244","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T08:12:39Z","timestamp":1519287159000},"page":"1179-1188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Molecular and clinical studies in 8 patients with Temple syndrome"],"prefix":"10.1111","volume":"93","author":[{"given":"G.","family":"Gillessen\u2010Kaesbach","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Humangenetik Universit\u00e4t zu L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Humangenetik 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