{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:00:38Z","timestamp":1792425638001,"version":"4.5.0"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1143767"],"award-info":[{"award-number":["APP1143767"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001171","name":"Cancer Institute NSW","doi-asserted-by":"publisher","award":["ID: 11\/ECF\/3\u201043"],"award-info":[{"award-number":["ID: 11\/ECF\/3\u201043"]}],"id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Children and young people are increasingly likely to receive information regarding inherited health risks relevant to their genetic relatives and themselves. We reviewed the literature to determine what children and young people (21 years and younger) understand about inherited conditions and their attitudes towards genetic testing. We screened 1815 abstracts to identify 20 studies representing the perspectives of 1811 children and young people between the ages of 6 and 21 years (1498 children or young people at general population\u2010level risk from 9 studies, 313 affected\/at risk from 15 studies). Children and young people at general population\u2010level risk demonstrated a basic understanding that disease predisposition can be inherited within families. Those affected by or at risk of genetic conditions inferred their genetic status from observable, relational characteristics within their family and the results of personal genetic testing if it had occurred, but some misunderstandings of important genetic concepts were evident. Children and young people expressed interest in and a willingness to undertake personal genetic testing, but also articulated concerns about the limitations and risks of testing. Paediatric patients require developmentally\u2010sensitive genetic counselling and support in navigating the unique landscape of their condition.<\/jats:p>","DOI":"10.1111\/cge.13253","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T13:23:42Z","timestamp":1521984222000},"page":"10-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Children and young people's understanding of inherited conditions and their attitudes towards genetic testing: A systematic review"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2134-2988","authenticated-orcid":false,"given":"B.C.","family":"McGill","sequence":"first","affiliation":[{"name":"Discipline of Paediatrics School of Women's and Children's Health  UNSW Sydney Kensington Australia"},{"name":"Behavioral Sciences Unit Proudly Supported by the Kids with Cancer Foundation, Kids Cancer Centre Sydney 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