{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:40:56Z","timestamp":1772160056222,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>\n                    We report findings from a male fetus of 26 weeks' gestational age with severe isolated intrauterine growth restriction (IUGR). Chromosomal microarray analysis (CMA) on amniotic fluid cells revealed a 1.06\u2010Mb duplication in 19q13.42 inherited from the healthy father. This duplication contains 34 genes including\n                    <jats:italic>ZNF331<\/jats:italic>\n                    , a gene encoding a zinc\u2010finger protein specifically imprinted (paternally expressed) in the placenta. Study of the\n                    <jats:italic>ZNF331<\/jats:italic>\n                    promoter by methylation\u2010specific\u2010multiplex ligation\u2010dependent probe amplification showed that the duplicated allele was not methylated in the fetus unlike in the father's genome, suggesting both copies of the\n                    <jats:italic>ZNF331<\/jats:italic>\n                    gene are expressed in the fetus. The anti\u2010ZNF331 immunohistochemical analysis confirmed that ZNF331 was expressed at higher levels in renal and placental tissues from this fetus compared to controls. Interestingly,\n                    <jats:italic>ZNF331<\/jats:italic>\n                    expression levels in the placenta have previously been reported to inversely correlate with fetal growth parameters. The original observation presented in this report showed that duplication of\n                    <jats:italic>ZNF331<\/jats:italic>\n                    could be a novel genetic cause of isolated IUGR and underlines the usefulness of CMA to investigate the genetic causes of isolated severe IUGR.\n                  <\/jats:p>","DOI":"10.1111\/cge.13449","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T02:42:43Z","timestamp":1537152163000},"page":"575-580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genomic duplication in the 19q13.42 imprinted region identified as a new genetic cause of intrauterine growth restriction"],"prefix":"10.1111","volume":"94","author":[{"given":"Graciane","family":"Petre","sequence":"first","affiliation":[{"name":"INSERM U1205 UFR Chimie Biologie  Grenoble France"},{"name":"Universit\u00e9 Grenoble\u2010Alpes  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Lor\u00e8s","sequence":"additional","affiliation":[{"name":"INSERM U1016 Institut Cochin  Paris France"},{"name":"Centre National de la Recherche Scientifique UMR8104  Paris France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 Paris\u2010Descartes, Sorbonne Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herv\u00e9","family":"Sartelet","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'anatomie et cytologie pathologiques CHU Grenoble\u2010Alpes  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lie","family":"Truffot","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique et Procr\u00e9ation CHU Grenoble\u2010Alpes  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brice","family":"Poreau","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique et Procr\u00e9ation CHU Grenoble\u2010Alpes  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Brandeis","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique et Procr\u00e9ation CHU Grenoble\u2010Alpes  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Martinez","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique et Procr\u00e9ation CHU Grenoble\u2010Alpes  Grenoble France"},{"name":"Equipe \u201cG\u00e9n\u00e9tique, Epig\u00e9n\u00e9tique, Th\u00e9rapies de l'Infertilit\u00e9\u201d IAB, INSERM 1209, CNRS UMR 5309  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Satre","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble\u2010Alpes  Grenoble France"},{"name":"D\u00e9partement de G\u00e9n\u00e9tique et Procr\u00e9ation CHU Grenoble\u2010Alpes  Grenoble France"},{"name":"Equipe \u201cG\u00e9n\u00e9tique, Epig\u00e9n\u00e9tique, Th\u00e9rapies de l'Infertilit\u00e9\u201d IAB, INSERM 1209, CNRS UMR 5309  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radu","family":"Harbuz","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique et Procr\u00e9ation CHU Grenoble\u2010Alpes  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre F.","family":"Ray","sequence":"additional","affiliation":[{"name":"Equipe \u201cG\u00e9n\u00e9tique, Epig\u00e9n\u00e9tique, Th\u00e9rapies de l'Infertilit\u00e9\u201d IAB, INSERM 1209, CNRS UMR 5309  Grenoble France"},{"name":"D\u00e9partement de Biochimie Toxicologie et Pharmacologie, UM GI\u2010DPI, CHU Grenoble\u2010Alpes  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Amblard","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique et Procr\u00e9ation CHU Grenoble\u2010Alpes  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Devillard","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique et Procr\u00e9ation CHU Grenoble\u2010Alpes  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga\u00eblle","family":"Vieville","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique et Procr\u00e9ation CHU Grenoble\u2010Alpes  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Berger","sequence":"additional","affiliation":[{"name":"INSERM U1205 UFR Chimie Biologie  Grenoble France"},{"name":"Universit\u00e9 Grenoble\u2010Alpes  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Simon","family":"Jouk","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble\u2010Alpes  Grenoble France"},{"name":"D\u00e9partement de G\u00e9n\u00e9tique et Procr\u00e9ation CHU Grenoble\u2010Alpes  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Vaiman","sequence":"additional","affiliation":[{"name":"INSERM U1016 Institut Cochin  Paris France"},{"name":"Centre National de la Recherche Scientifique UMR8104  Paris France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 Paris\u2010Descartes, Sorbonne Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aminata","family":"Tour\u00e9","sequence":"additional","affiliation":[{"name":"INSERM U1016 Institut Cochin  Paris France"},{"name":"Centre National de la Recherche Scientifique UMR8104  Paris France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 Paris\u2010Descartes, Sorbonne Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8873-8098","authenticated-orcid":false,"given":"Charles","family":"Coutton","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble\u2010Alpes  Grenoble France"},{"name":"D\u00e9partement de G\u00e9n\u00e9tique et Procr\u00e9ation CHU Grenoble\u2010Alpes  Grenoble France"},{"name":"Equipe \u201cG\u00e9n\u00e9tique, Epig\u00e9n\u00e9tique, Th\u00e9rapies de l'Infertilit\u00e9\u201d IAB, INSERM 1209, CNRS UMR 5309  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Bidart","sequence":"additional","affiliation":[{"name":"INSERM U1205 UFR Chimie Biologie  Grenoble France"},{"name":"Universit\u00e9 Grenoble\u2010Alpes  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00033.2015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2005.04.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90491-Z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13669-013-0041-z"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.06.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-08-0264"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20795"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2015.09.003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2009.12.012"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.54"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2015.02.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.03.001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.9019"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.173252"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920371604150429155255"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq272"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2014.2687"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1501"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcge.13449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cge.13449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cge.13449","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cge.13449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T18:44:37Z","timestamp":1694285077000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cge.13449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,17]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/cge.13449"],"URL":"https:\/\/doi.org\/10.1111\/cge.13449","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/CGE.13449\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.13449\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.13449\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.13449\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.13449\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.13449\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.13449\/v2\/response1","asserted-by":"object"}]},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,17]]},"assertion":[{"value":"2018-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}