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Different mutations in various members of these type V IF proteins produce a staggering range of human disease phenotypes, which collectively have been termed \u201claminopathies.\u201d Compelling examples are the wide range of inherited disorders that result from rare variants in\n                    <jats:italic>LMNA<\/jats:italic>\n                    encoding lamin A\/C. These laminopathies include skeletal and cardiac muscle disorders, neuropathies, multisystem progeroid disorders, and lipodystrophies, of which the latter are associated with several metabolic complications. Functions of lamin A\/C that have been shown to be compromised by distinct mutations in\n                    <jats:italic>LMNA<\/jats:italic>\n                    include loss of nuclear structural integrity, altered interaction with transcription factors, and changes to post\u2010translational processing of pre\u2010lamins. Recently, evidence has emerged that certain\n                    <jats:italic>LMNA<\/jats:italic>\n                    mutations, such as those causing partial lipodystrophy, alter the interaction between chromatin and lamin A, in turn affecting the spatial orientation and distribution of chromatin within the nucleus. Because chromatin organization is exquisitely tied to global patterns of gene expression, the findings suggest a novel mechanism to explain the tissue\u2010specific impact of a subset of laminopathy\u2010associated\n                    <jats:italic>LMNA<\/jats:italic>\n                    mutations.\n                  <\/jats:p>","DOI":"10.1111\/cge.13455","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T03:39:12Z","timestamp":1538537952000},"page":"199-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Complex effects of laminopathy mutations on nuclear structure and function"],"prefix":"10.1111","volume":"95","author":[{"given":"Rosettia","family":"Ho","sequence":"first","affiliation":[{"name":"Departments of Biochemistry and Medicine, and Robarts Research Institute Schulich School of Medicine and Dentistry, Western University  London Ontario 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