{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:26:12Z","timestamp":1748132772456,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Biallelic <jats:italic>exostosin\u20102<\/jats:italic> (<jats:italic>EXT2<\/jats:italic>) pathogenic variants have been described as the cause of the Seizures\u2010Scoliosis\u2010Macrocephaly syndrome (OMIM 616682) characterized by intellectual disability, facial dysmorphisms and seizures. More recently, it has been proposed to rename this disorder with the acronym AREXT2 (autosomal recessive EXT2\u2010related syndrome). Here, we report the third family affected by AREXT2 syndrome, harboring compound missense variants in <jats:italic>EXT2<\/jats:italic>, p.Asp227Asn, and p.Tyr608Cys. In addition, our patients developed multiple exostoses, which were not observed in the previously described families. AREXT2 syndrome can be considered as a multiorgan Congenital Disorder of Glycosylation caused by a significant, but non\u2010lethal, decrease in EXT2 expression, thereby affecting the synthesis of the heparan sulfate proteoglycans, which is relevant in many physiological processes. Our finding expands the clinical and molecular spectrum of the AREXT2 syndrome and suggests a possible genotype\/phenotype correlation in the development of the exostoses.<\/jats:p>","DOI":"10.1111\/cge.13458","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T02:52:39Z","timestamp":1538794359000},"page":"165-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Novel <i>exostosin\u20102<\/i> missense variants in a family with autosomal recessive exostosin\u20102\u2010related syndrome: further evidences on the phenotype"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5299-6036","authenticated-orcid":false,"given":"Mattia","family":"Gentile","sequence":"first","affiliation":[{"name":"Department of Medical Genetics Hospital Di Venere, Local Sanitary Agency of BARI  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6543-6225","authenticated-orcid":false,"given":"Emanuele","family":"Agolini","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics Ospedale Pediatrico Bambino Ges\u00f9  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Cocciadiferro","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics Ospedale Pediatrico Bambino Ges\u00f9  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina","family":"Ficarella","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Hospital Di Venere, Local Sanitary Agency of BARI  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Ponzi","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Hospital Di Venere, Local Sanitary Agency of BARI  Bari 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