{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:40:56Z","timestamp":1772160056091,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T00:00:00Z","timestamp":1547164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81420108021,81730067,81622033"],"award-info":[{"award-number":["81420108021,81730067,81622033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>\n                    Developmental dysplasia of the hip (DDH) is one of the most common congenital malformations and covers a spectrum of hip disorders from mild dysplasia to irreducible dislocation. The pathological mechanisms of DDH are poorly understood, which hampers the development of diagnostic tools and treatments. To gain insight into its disease mechanism, we explored the potential biological processes that underlie DDH by integrating pathway analysis tools and performing a genome\u2010wide association study (GWAS). A total of 406 DDH\u2010associated genes (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001) were identified by our GWAS using a Chinese Han cohort consisting of 386 DDH cases and 500 healthy controls (Set A). We verified the significant loci (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u200910\n                    <jats:sup>\u22125<\/jats:sup>\n                    ) in another Chinese Han cohort consisting of 574 DDH patients and 569 healthy controls (Set B). An intronic Single Nucleotide Polymorphism (SNP) (rs61930502) showed significant association in Set A and Set B (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20092.65 \u00d7 10\n                    <jats:sup>\u22127<\/jats:sup>\n                    and 2.0 \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    , respectively). The minor allele, rs61930502\u2010A, which tended to prevent DDH showed a dominant effect. Heat shock 70\u2009kDa protein 8 (HSPA8) showed the most direct interactions with other proteins which were coded by DDH\u2010associated genes in the protein\u2010protein interaction analysis. Interestingly, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis suggested a relation between DDH and the genes involved in type II diabetes mellitus pathway (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.0067). Our genetic and protein interaction evidence could open avenues for future studies of DDH.\n                  <\/jats:p>","DOI":"10.1111\/cge.13483","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T02:29:48Z","timestamp":1543890588000},"page":"345-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A genome\u2010wide association study identifies new genes associated with developmental dysplasia of the hip"],"prefix":"10.1111","volume":"95","author":[{"given":"Wenjin","family":"Yan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Hao","sequence":"additional","affiliation":[{"name":"Center of Diagnosis and Treatment for Developmental Dysplasia of the Hip, Nanjing Zhongyangmen Community Health Service Center Kang'ai Hospital  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyan","family":"Tang","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital, Institute of Metabolism and Integrative Biology, School of Life Sciences Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Dai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing 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Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingquan","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongquan","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Ikegawa","sequence":"additional","affiliation":[{"name":"Laboratory of Bone and Joint Diseases, Center for Integrative Medical Sciences, RIKEN  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huajian","family":"Teng","sequence":"additional","affiliation":[{"name":"Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC) Nanjing University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2552-9686","authenticated-orcid":false,"given":"Qing","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum 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