{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:18:01Z","timestamp":1790878681586,"version":"4.1.0"},"reference-count":141,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014653","name":"NIHR Manchester Biomedical Research Centre","doi-asserted-by":"publisher","award":["IS\u2010BRC\u20101215\u201020007"],"award-info":[{"award-number":["IS\u2010BRC\u20101215\u201020007"]}],"id":[{"id":"10.13039\/100014653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ovarian cancer is the fourth most common cause of cancer\u2010related death in women in the developed world, and one of the most heritable cancers. One of the most significant risk factors for epithelial ovarian cancer (EOC) is a family history of breast and\/or ovarian cancer. Combined risk factors can be used in models to stratify risk of EOC, and aid in decisions regarding risk\u2010reduction strategies. Germline pathogenic variants in EOC susceptibility genes including those involved in homologous recombination and mismatch repair pathways are present in approximately 22% to 25% of EOC. These genes are associated with an estimated lifetime risk of EOC of 13% to 60% for\n                    <jats:italic>BRCA1<\/jats:italic>\n                    variants and 10% to 25% for\n                    <jats:italic>BRCA2<\/jats:italic>\n                    variants, with lower risks associated with remaining genes. Genome\u2010wide association studies have identified single nucleotide polymorphisms (SNPs) thought to explain an additional 6.4% of the familial risk of ovarian cancer, with 34 susceptibility loci identified to date. However, an unknown proportion of the genetic component of EOC risk remains unexplained. This review comprises an overview of individual genes and SNPs suspected to contribute to risk of EOC, and discusses use of a polygenic risk score to predict individual cancer risk more accurately.\n                  <\/jats:p>","DOI":"10.1111\/cge.13566","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T01:08:05Z","timestamp":1558055285000},"page":"54-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Epithelial ovarian cancer risk: A review of the current genetic landscape"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8900-0645","authenticated-orcid":false,"given":"Nicola","family":"Flaum","sequence":"first","affiliation":[{"name":"Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma J.","family":"Crosbie","sequence":"additional","affiliation":[{"name":"Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester Manchester Academic Health Science Centre  Manchester UK"},{"name":"Department of Gynaecology, St Mary's Hospital, Manchester University NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Edmondson","sequence":"additional","affiliation":[{"name":"Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester Manchester Academic Health Science Centre  Manchester UK"},{"name":"Department of Gynaecology, St Mary's Hospital, Manchester University NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3184-0817","authenticated-orcid":false,"given":"Miriam J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester Manchester Academic Health Science Centre  Manchester UK"},{"name":"Manchester Centre for Genomic Medicine, St. Mary's Hospital, Manchester University NHS Foundation Trust Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafydd G.","family":"Evans","sequence":"additional","affiliation":[{"name":"Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester Manchester Academic Health Science Centre  Manchester UK"},{"name":"Manchester Centre for Genomic Medicine, St. Mary's Hospital, Manchester University NHS Foundation Trust Manchester Academic Health Science Centre  Manchester UK"},{"name":"Prevention Breast Cancer Centre and Nightingale Breast Screening Centre University Hospital of South Manchester  Manchester UK"},{"name":"Department of Cancer Genetics, The Christie NHS Foundation Trust  Manchester UK"},{"name":"Manchester Breast Centre, Manchester Cancer Research Centre University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-015-0650-8"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-3911"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt333"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2016.0084"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62146-7"},{"key":"e_1_2_5_8_1","volume-title":"Cancer Stat Facts: Ovarian Cancer","author":"Surveillance, Epidemiology, and End Results (SEER) Program","year":"2018"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1816"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.17226\/21841"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10166"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2224"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.893"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv214"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4292-1"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.0873"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.08.320"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.06.010"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23438"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.02.006"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000601)88:11<2584::AID-CNCR22>3.0.CO;2-5"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2016.03.015"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.01.534"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10148.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-102015"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000217"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2013.22.Sup17.S23"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.06.088"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2013.24.2.135"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61687-1"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001200"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.11.010"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0515"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.539"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.03.031"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70322-4"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9207-9"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0394"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S66824"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw142"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1457"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-017-3770-y"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-2287"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-0324"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.2741\/4230"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3934"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199611073351901"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11310"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8091231"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.06.71"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.2140"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-004-9552-0"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1371"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.8545"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.1703"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg816"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.07.002"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/26.5.1179"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-3078-4"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.2408"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.569"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.5495"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1998.5226"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2016.04.006"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105719200"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.05.022"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks270"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3958"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00304-X"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1627"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.955"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7792600"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgv138"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.07.015"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.05.040"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21047"},{"key":"e_1_2_5_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23601"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200107000-00003"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2005.00537.x"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.01.005"},{"key":"e_1_2_5_81_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0619"},{"key":"e_1_2_5_82_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/341723"},{"key":"e_1_2_5_83_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.743"},{"key":"e_1_2_5_84_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314057"},{"key":"e_1_2_5_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.12.003"},{"key":"e_1_2_5_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2009.02.004"},{"key":"e_1_2_5_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu172"},{"key":"e_1_2_5_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.02.009"},{"key":"e_1_2_5_89_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.068130"},{"key":"e_1_2_5_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4563-x"},{"key":"e_1_2_5_91_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a001008"},{"issue":"20","key":"e_1_2_5_92_1","first-page":"6643","article-title":"Li\u2010Fraumeni and related syndromes: correlation between tumor type, family structure and TP53 genotype","volume":"63","author":"Olivier M","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_5_93_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.2956"},{"key":"e_1_2_5_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-018-0005-9"},{"key":"e_1_2_5_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-015-3429-9"},{"key":"e_1_2_5_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.01.537"},{"key":"e_1_2_5_97_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186043"},{"key":"e_1_2_5_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2016.01.006"},{"key":"e_1_2_5_99_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-0595"},{"key":"e_1_2_5_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12028"},{"key":"e_1_2_5_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-018-0089-z"},{"key":"e_1_2_5_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2012.175"},{"key":"e_1_2_5_103_1","doi-asserted-by":"publisher","DOI":"10.1159\/000431352"},{"key":"e_1_2_5_104_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.69.9330"},{"key":"e_1_2_5_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn442"},{"key":"e_1_2_5_106_1","volume-title":"Endometrial and Ovarian Cancer Screening and Prevention in Women with Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer)","author":"Lu KH","year":"2016"},{"key":"e_1_2_5_107_1","volume-title":"Genetic\/familial high\u2010risk assessment: breast and ovarian","author":"National Comprehensive Cancer Network","year":"2018"},{"key":"e_1_2_5_108_1","first-page":"CD012464","article-title":"Risk\u2010reducing bilateral salpingo\u2010oophorectomy in women with brca1 or brca2 mutations","volume":"8","author":"Eleje GU","year":"2018","journal-title":"Coch Database Syst Rev"},{"key":"e_1_2_5_109_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv033"},{"key":"e_1_2_5_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmq030"},{"key":"e_1_2_5_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.12.003"},{"key":"e_1_2_5_112_1","article-title":"Ovarian cancer including fallopian tube cancer and primary peritoneal","author":"National Comprehensive Cancer Network","year":"2018","journal-title":"Cancer"},{"key":"e_1_2_5_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29321"},{"key":"e_1_2_5_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03445"},{"key":"e_1_2_5_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03443"},{"key":"e_1_2_5_116_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq509"},{"key":"e_1_2_5_117_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900212"},{"key":"e_1_2_5_118_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.9589"},{"key":"e_1_2_5_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60893-8"},{"key":"e_1_2_5_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60892-6"},{"key":"e_1_2_5_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70214-5"},{"key":"e_1_2_5_122_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.9215"},{"key":"e_1_2_5_123_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105535"},{"key":"e_1_2_5_124_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.2728"},{"key":"e_1_2_5_125_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw435.26"},{"key":"e_1_2_5_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32440-6"},{"key":"e_1_2_5_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.02.017"},{"key":"e_1_2_5_128_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1810858"},{"key":"e_1_2_5_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3826"},{"key":"e_1_2_5_130_1","volume-title":"BOADICEA","author":"Centre for Cancer Genetic Epidemiology","year":"2016"},{"key":"e_1_2_5_131_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv036"},{"key":"e_1_2_5_132_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0603-4350"},{"key":"e_1_2_5_133_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115052108"},{"key":"e_1_2_5_134_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-0951"},{"key":"e_1_2_5_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15174"},{"key":"e_1_2_5_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-018-0005-9"},{"issue":"6","key":"e_1_2_5_137_1","first-page":"1457","article-title":"Estimates of the gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence","volume":"57","author":"Ford D","year":"1995","journal-title":"Am J Human Genet"},{"key":"e_1_2_5_138_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.06.71"},{"key":"e_1_2_5_139_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx265"},{"key":"e_1_2_5_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1403-8"},{"issue":"12","key":"e_1_2_5_141_1","first-page":"3325","article-title":"Contributions of ATM mutations to familial breast and ovarian cancer","volume":"63","author":"Thorstenson YR","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_5_142_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.743"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cge.13566","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cge.13566","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cge.13566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T14:23:34Z","timestamp":1694096614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cge.13566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,29]]},"references-count":141,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/cge.13566"],"URL":"https:\/\/doi.org\/10.1111\/cge.13566","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/CGE.13566\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.13566\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.13566\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.13566\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.13566\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.13566\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,29]]},"assertion":[{"value":"2019-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}