{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:02Z","timestamp":1772160062937,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>SATB2<\/jats:italic>\n                    \u2010associated syndrome (SAS) is a recently identified disorder characterized by neurodevelopmental deficits and craniofacial anomalies. Assessments of speech, language, and feeding\u2010related issues were conducted among 61 individuals with SAS (median age = 86 months, range = 26 months to 29\u2009years of age). Individuals with SAS were mostly non\u2010verbal communicators (72.1%) with severe deficits in both language comprehension and expression. The majority of individuals had receptive vocabulary skills of a child younger than 3\u2009years of age. Based on parent report, the average spoken lexicon was 28.6 (SD = 84.6, n = 55) with a range of 0 to 500 (median = 5 words). All of the individuals with SAS with enough verbal ability either showed signs of childhood apraxia of speech or already had a diagnosis (n = 40) and 73.3% exhibited problems with reliable communication with unfamiliar partners. Hypernasal resonance (17.8%) due to velopharyngeal insufficiency secondary to a history of cleft palate and\/or apraxic palatal movement (60.0% of hypernasal patients with no history of cleft palate), problems with chewing (68.2%), overstuffing the mouth with solids (64.9%), pharyngeal phase dysphagia (60.8%), and sialorrhea (63.3%) were common in this population. Mutation type was not predictive of receptive or expressive language abilities. We developed language and communication treatment recommendations based on these findings.\n                  <\/jats:p>","DOI":"10.1111\/cge.13619","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:08:12Z","timestamp":1565222892000},"page":"485-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Speech, language, and feeding phenotypes of\n                    <i>SATB2<\/i>\n                    \u2010associated syndrome"],"prefix":"10.1111","volume":"96","author":[{"given":"Ashlen","family":"Thomason","sequence":"first","affiliation":[{"name":"Audiology\/Speech Pathology Department Arkansas Children's Hospital  Little Rock Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Pankey","sequence":"additional","affiliation":[{"name":"Audiology\/Speech Pathology Department Arkansas Children's Hospital  Little Rock Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth","family":"Nutt","sequence":"additional","affiliation":[{"name":"Audiology\/Speech Pathology Department Arkansas Children's Hospital  Little Rock Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisling R.","family":"Caffrey","sequence":"additional","affiliation":[{"name":"Health Outcomes Department, College of Pharmacy University of Rhode Island  Kingston Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8235-6200","authenticated-orcid":false,"given":"Yuri A.","family":"Zarate","sequence":"additional","affiliation":[{"name":"Section of Genetics and Metabolism University of Arkansas for Medical Sciences  Little Rock Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38022"},{"key":"e_1_2_8_3_1","volume-title":"GeneReviews\u00ae","author":"Zarate 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