{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:02:20Z","timestamp":1788498140269,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"Savoy Foundation","doi-asserted-by":"publisher","award":["R01DC011835"],"award-info":[{"award-number":["R01DC011835"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007812","name":"University of Washington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mutations in more than 150 genes are responsible for inherited hearing loss, with thousands of different, severe causal alleles that vary among populations. The Israeli Jewish population includes communities of diverse geographic origins, revealing a wide range of deafness\u2010associated variants and enabling clinical characterization of the associated phenotypes. Our goal was to identify the genetic causes of inherited hearing loss in this population, and to determine relationships among genotype, phenotype, and ethnicity. Genomic DNA samples from informative relatives of 88 multiplex families, all of self\u2010identified Jewish ancestry, with either non\u2010syndromic or syndromic hearing loss, were sequenced for known and candidate deafness genes using the HEar\u2010Seq gene panel. The genetic causes of hearing loss were identified for 60% of the families. One gene was encountered for the first time in human hearing loss:\n                    <jats:italic>ATOH1<\/jats:italic>\n                    (Atonal), a basic helix\u2010loop\u2010helix transcription factor responsible for autosomal dominant progressive hearing loss in a five\u2010generation family. Our results show that genomic sequencing with a gene panel dedicated to hearing loss is effective for genetic diagnoses in a diverse population. Comprehensive sequencing enables well\u2010informed genetic counseling and clinical management by medical geneticists, otolaryngologists, audiologists, and speech therapists and can be integrated into newborn screening for deafness.\n                  <\/jats:p>","DOI":"10.1111\/cge.13817","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T23:26:17Z","timestamp":1595287577000},"page":"353-364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Spectrum of genes for inherited hearing loss in the Israeli Jewish population, including the novel human deafness gene\n                    <scp>\n                      <i>ATOH1<\/i>\n                    <\/scp>"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7958-304X","authenticated-orcid":false,"given":"Zippora","family":"Brownstein","sequence":"first","affiliation":[{"name":"Department of Human Molecular Genetics &amp; Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3897-1238","authenticated-orcid":false,"given":"Suleyman","family":"Gulsuner","sequence":"additional","affiliation":[{"name":"Departments of Genome Sciences and Medicine University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8875-0310","authenticated-orcid":false,"given":"Tom","family":"Walsh","sequence":"additional","affiliation":[{"name":"Departments of Genome Sciences and Medicine University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3489-4095","authenticated-orcid":false,"given":"F\u00e1bio T.A.","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics &amp; Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0787-4216","authenticated-orcid":false,"given":"Shahar","family":"Taiber","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics &amp; Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0955-0802","authenticated-orcid":false,"given":"Ofer","family":"Isakov","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Genome Sciences and Medicine University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9735-7596","authenticated-orcid":false,"given":"Mor","family":"Bordeynik\u2010Cohen","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics &amp; Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Birkan","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics &amp; Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"},{"name":"Raphael Recanati Genetic Institute, Rabin Medical Center\u2013Beilinson Hospital Tel Aviv University Felsenstein Medical Research Center  Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weise","family":"Chang","sequence":"additional","affiliation":[{"name":"Laboratory of Cochlear Development National Institute on Deafness and Other Communication Disorders, NIH  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2619-5662","authenticated-orcid":false,"given":"Silvia","family":"Casadei","sequence":"additional","affiliation":[{"name":"Departments of Genome Sciences and Medicine University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8092-3144","authenticated-orcid":false,"given":"Nada","family":"Danial\u2010Farran","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics &amp; Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"},{"name":"Genetics Institute, Ha'Emek Medical Center  Afula Israel"},{"name":"Rappaport Faculty of Medicine, Technion  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8061-5173","authenticated-orcid":false,"given":"Amal","family":"Abu\u2010Rayyan","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics &amp; Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Biological Sciences Bethlehem University  Bethlehem Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8311-481X","authenticated-orcid":false,"given":"Ryan","family":"Carlson","sequence":"additional","affiliation":[{"name":"Departments of Genome Sciences and Medicine University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5820-5234","authenticated-orcid":false,"given":"Lara","family":"Kamal","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Bethlehem University  Bethlehem Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0087-2525","authenticated-orcid":false,"given":"Asgeir \u00d6.","family":"Arnth\u00f3rsson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, BioMedical Center, Faculty of Medicine University of Iceland  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7958-4816","authenticated-orcid":false,"given":"Meirav","family":"Sokolov","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics &amp; Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Schneider Children's Medical Center  Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7802-9589","authenticated-orcid":false,"given":"Dror","family":"Gilony","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics &amp; Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Schneider Children's Medical Center  Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1252-8641","authenticated-orcid":false,"given":"Noga","family":"Lipschitz","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics &amp; Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2631-756X","authenticated-orcid":false,"given":"Moshe","family":"Frydman","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics &amp; Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"},{"name":"Institute of Human Genetics, Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4084-078X","authenticated-orcid":false,"given":"Bella","family":"Davidov","sequence":"additional","affiliation":[{"name":"Raphael Recanati Genetic Institute, Rabin Medical Center\u2013Beilinson Hospital Tel Aviv University Felsenstein Medical Research Center  Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Macarov","sequence":"additional","affiliation":[{"name":"Department of Human Genetics and Metabolic Diseases Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Sagi","sequence":"additional","affiliation":[{"name":"Department of Human Genetics and Metabolic Diseases Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5991-4534","authenticated-orcid":false,"given":"Chana","family":"Vinkler","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics, Wolfson Medical Center  Holon Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Poran","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6899-9223","authenticated-orcid":false,"given":"Reuven","family":"Sharony","sequence":"additional","affiliation":[{"name":"Genetics Institute, Meir Medical Center, Kfar Saba and Sackler Faculty of Medicine, Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadra","family":"Samra","sequence":"additional","affiliation":[{"name":"Ziv Medical Center  Zefat Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na'ama","family":"Zvi","sequence":"additional","affiliation":[{"name":"Department of Human Genetics and Metabolic Diseases Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagit","family":"Baris\u2010Feldman","sequence":"additional","affiliation":[{"name":"Genetics Institute, Tel\u2010Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amihood","family":"Singer","sequence":"additional","affiliation":[{"name":"Community Genetics Department Public Health Services, Ministry of Health  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6905-3034","authenticated-orcid":false,"given":"Ophir","family":"Handzel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery Tel\u2010Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8093-6567","authenticated-orcid":false,"given":"Ronna","family":"Hertzano","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa","family":"Ali\u2010Naffaa","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics &amp; Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"},{"name":"Human Genetics Institute, Lady Davis Carmel Medical Center  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa","family":"Ruhrman\u2010Shahar","sequence":"additional","affiliation":[{"name":"Raphael Recanati Genetic Institute, Rabin Medical Center\u2013Beilinson Hospital Tel Aviv University Felsenstein Medical Research Center  Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0491-9068","authenticated-orcid":false,"given":"Ory","family":"Madgar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efrat","family":"Sofrin\u2010Drucker","sequence":"additional","affiliation":[{"name":"Raphael Recanati Genetic Institute, Rabin Medical Center\u2013Beilinson Hospital Tel Aviv University Felsenstein Medical Research Center  Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9563-7914","authenticated-orcid":false,"given":"Amir","family":"Peleg","sequence":"additional","affiliation":[{"name":"Human Genetics Institute, Lady Davis Carmel Medical Center  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4817-7492","authenticated-orcid":false,"given":"Morad","family":"Khayat","sequence":"additional","affiliation":[{"name":"Genetics Institute, Ha'Emek Medical Center  Afula Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mordechai","family":"Shohat","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics &amp; Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"},{"name":"Sheba Cancer Research Center, Sheba Medical Center  Tel Hashomer Israel"},{"name":"Institute of Medical Genetics, Maccabi HMO  Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9076-8157","authenticated-orcid":false,"given":"Lina","family":"Basel\u2010Salmon","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics &amp; Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"},{"name":"Raphael Recanati Genetic Institute, Rabin Medical Center\u2013Beilinson Hospital Tel Aviv University Felsenstein Medical Research Center  Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8094-7429","authenticated-orcid":false,"given":"Elon","family":"Pras","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics &amp; Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"},{"name":"Institute of Human Genetics, Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6869-6727","authenticated-orcid":false,"given":"Dorit","family":"Lev","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics &amp; Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"},{"name":"Institute of Medical Genetics, Wolfson Medical Center  Holon Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-7486","authenticated-orcid":false,"given":"Eirikur","family":"Steingrimsson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, BioMedical Center, Faculty of Medicine University of Iceland  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9913-6124","authenticated-orcid":false,"given":"Noam","family":"Shomron","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7367-8697","authenticated-orcid":false,"given":"Matthew W.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Laboratory of Cochlear Development National Institute on Deafness and Other Communication Disorders, NIH  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3227-4685","authenticated-orcid":false,"given":"Moien N.","family":"Kanaan","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Bethlehem University  Bethlehem Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1084-3066","authenticated-orcid":false,"given":"Stavit","family":"Allon\u2010Shalev","sequence":"additional","affiliation":[{"name":"Genetics Institute, Ha'Emek Medical Center  Afula Israel"},{"name":"Rappaport Faculty of Medicine, Technion  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9426-1743","authenticated-orcid":false,"given":"Mary\u2010Claire","family":"King","sequence":"additional","affiliation":[{"name":"Departments of Genome Sciences and Medicine University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4913-251X","authenticated-orcid":false,"given":"Karen B.","family":"Avraham","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics &amp; Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1616601"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31678-6"},{"key":"e_1_2_10_4_1","unstructured":"World Health Organization. Deafness and hearing loss.http:\/\/www.who.int\/news-room\/fact-sheets\/detail\/deafness-and-hearing-loss. Updated March 2020. Accessed May 2 2020."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820910377"},{"issue":"5","key":"e_1_2_10_6_1","first-page":"703","article-title":"Hearing impairment and incident dementia and cognitive decline in older adults: the Health ABC Study","volume":"72","author":"Deal JA","year":"2017","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"e_1_2_10_7_1","unstructured":"Van CampG&SmithRJH.Hereditary hearing loss homepage.http:\/\/hereditaryhearingloss.org. Updated April 2020. Accessed May 2 2020."},{"key":"e_1_2_10_8_1","unstructured":"Deafness Variation Database.http:\/\/deafnessvariationdatabase.org\/. Accessed May 2 2020."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.08.006"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2015.07.007"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.09.001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-012-1235-6"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.100115997"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.73"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/35098506"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1960.tb01732.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/0301446032000159255"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181aabd7f"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-9-r89"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004390051009"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11124-2"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815591156"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1012989107"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2013.232"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-018-0218-z"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/36579"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079791"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0295-17.2017"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.6.374"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.02.013"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1086\/522090"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0298-171"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2014.60"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2013.0328"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1089\/gte.2007.0107"},{"issue":"4","key":"e_1_2_10_36_1","first-page":"380","article-title":"Two novel missense mutations in the TECTA gene in Korean families with autosomal dominant nonsyndromic hearing loss","volume":"40","author":"Sagong B","year":"2010","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0708-z"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000366514"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.4.8435"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/93.2.99"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201611"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000936"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001689"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134527"},{"issue":"1","key":"e_1_2_10_45_1","first-page":"77","article-title":"Whole exome sequencing in adult\u2010onset hearing loss reveals a high load of predicted pathogenic variants in known deafness\u2010associated genes and identifies new candidate genes","volume":"11","author":"Lewis MA","year":"2018","journal-title":"BMC Med Genet"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1007983107"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.172"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.73"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.10.2495"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2010.12.002"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.05.014"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.722124"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5420-11.2012"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0818-12.2012"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.6.1185"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2018.12.025"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008409"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.24052"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23630"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcge.13817","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cge.13817","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cge.13817","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cge.13817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T23:30:57Z","timestamp":1693870257000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cge.13817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,24]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/cge.13817"],"URL":"https:\/\/doi.org\/10.1111\/cge.13817","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.06.11.144790","asserted-by":"object"}]},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,24]]},"assertion":[{"value":"2020-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}