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The majority of cases is miscarried at early developmental stages. In consequence of genomic imprinting, parental origin affects the phenotype of triploid pregnancies as well as the prevalence and spectrum of related maternal complications. Distinctive ultrasound features of both triploid phenotypes as well as characteristic patterns of biochemical markers may be useful in diagnosis. Molecular confirmation of the parental origin allows to predict the risk of complications, such as gestational trophoblastic neoplasia, hyperthyroidism, hypertension, or preeclampsia associated with the paternal origin of triploidy. Diagnosis of partial hydatidiform mole associated with diandric triploidy is challenging especially in the first trimester pregnancy loss due to the limitations of both histopathology and ultrasound. We present important clinical aspects of triploid pregnancies and indicate unresolved issues demanding further studies.<\/jats:p>","DOI":"10.1111\/cge.14003","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T03:44:50Z","timestamp":1621914290000},"page":"368-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Triploid pregnancy\u2013Clinical implications"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0547-6388","authenticated-orcid":false,"given":"Diana","family":"Massalska","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology and Obstetrics Centre of Postgraduate Medical Education  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Bijok","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology and Obstetrics Centre of Postgraduate Medical 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